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| MBGL5036 | Molecular Genetics of Prokaryotes | 3+0+0 | ECTS:7.5 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of MOLECULAR BIOLOGY and GENETICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Prof. Dr. Kadriye İNAN BEKTAŞ | | Co-Lecturer | | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | With the Molecular Genetics of Prokaryotes course, it is aimed to examine the gene structures, functions, mechanisms of gene expression and control systems of prokaryotes at the molecular level and present them to the students. Students from different disciplines will be informed about the molecular genetics of procarcots. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | Learning prokaryotic gene and genome structures-properties | 2,5 | 1,5, | | PO - 2 : | Understanding DNA replication and repair mechanisms | 2,5 | 1,5, | | PO - 3 : | Understanding the molecular mechanisms of transcription and translation | 2,5 | 1,5, | | PO - 4 : | Understanding gene expression and control mechanisms | 2,5 | 1,5, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Course content; To learn the properties of nucleic acid molecules that form the basis of the genetic information of organisms, to understand the organization and packaging of prokaryotic chromosomes, to understand how the processes that are essential for reproduction and gene expression such as DNA replication, transcription and translation occur in prokaryotic organisms, genetic code and its basics, gene expression pre-transcription, transcription. To understand the mechanisms of regulation in the initiation of translation and initiation of translation, to understand the regulatory proteins that play a role in the regulation of gene expression and to understand the principles of operation. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Prokaryotic gene structures and properties | | | Week 2 | Prokaryotic genome organization and chromatin structures | | | Week 3 | Mutation and gene transfer | | | Week 4 | DNA replication mechanism and control | | | Week 5 | DNA repair mechanisms | | | Week 6 | Molecular mechanism of transcription | | | Week 7 | Transcription factors and transcription control | | | Week 8 | Post-transcriptional events and regulation | | | Week 9 | Exam | | | Week 10 | Translation mechanism and translation accuracy mechanisms | | | Week 11 | Protein localization | | | Week 12 | gene control systems | | | Week 13 | evolution of the genome | | | Week 14 | resentation | | | Week 15 | RNA processes | | | Week 16 | End of term exam | | | |
| 1 | Molecular Genetics of Bacteria : Jeremy W. Dale, Simon F. Park, 2010 | | | |
| 1 | Molecular Biology of the Gene, 6th Edition, Watson, Baker, Bell, Gann, Levine, Losick, 2008 | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | | | 30 | | Presentation | 14 | | | 20 | | End-of-term exam | 16 | | | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 4 | 10 | 40 | | Arasınav için hazırlık | 3 | 8 | 24 | | Arasınav | 2 | 1 | 2 | | Dönem sonu sınavı için hazırlık | 3 | 14 | 42 | | Dönem sonu sınavı | 1 | 2 | 2 | | Diğer 1 | 4 | 10 | 40 | | Total work load | | | 192 |
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