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| MBG4030 | epigenetics | 2+0+0 | ECTS:4 | | Year / Semester | Spring Semester | | Level of Course | First Cycle | | Status | Elective | | Department | DEPARTMENT of MOLECULAR BIOLOGY and GENETICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Doç. Dr. Selcen ÇELİK UZUNER | | Co-Lecturer | | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | The aim of the course is to understand the mechanism of epigenetic modifications in DNA and histones, the structure of chromatin and their role in gene regulation, how epigenetic modifications function during normal development and their relationship with diseases. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Aware of the epigenetic modifications that occur in DNA and histone and to understand the relationship between epigenetic modifications | 11 | | | LO - 2 : | Understand the chromtin structure | 11 | | | LO - 3 : | Understand the effect of epigenetic mechanisms on gene regulation | 11 | | | LO - 4 : | Understand the importance of epigenetic mechanisms in the normal development process and the formation and course of diseases | 11 | | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| This course includes the definition of epigenetic modifications, their types, and understanding of their interrelationships. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introduction to epigenetics | | | Week 2 | Chromatin | | | Week 3 | DNA methylation | | | Week 4 | Histone modifications | | | Week 5 | Chromatin modifying proteins and RNA | | | Week 6 | The role of epigenetics on embryogenesis and cellular differentiation | | | Week 7 | Population epigenetics and aging | | | Week 8 | Cancer epigenetics | | | Week 9 | Mid-term exam | | | Week 10 | Cancer epigenetics | | | Week 11 | Neuroepigenetics | | | Week 12 | Neuroepigenetics | | | Week 13 | Nutritional epigenetics | | | Week 14 | Epigenetics in immune system | | | Week 15 | Epigenome and environmental factors | | | Week 16 | Final Exam | | | |
| 1 | Human Epigenetics: How Science Works, Carsten Carlberg ? Ferdinand Molnár, Springer, 2019, ISBN 978-3-030-22906-1 ISBN 978-3-030-22907-8 (eBook)
https://doi.org/10.1007/978-3-030-22907-8 | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | | | 30 | | In-term studies (second mid-term exam) | 11 | | | 20 | | End-of-term exam | 16 | | | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Arasınav | 2 | 1 | 2 | | Dönem sonu sınavı | 2 | 1 | 2 | | Total work load | | | 46 |
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