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| MBG4024 | Industrial Biotechnology | 3+0+0 | ECTS:4 | | Year / Semester | Spring Semester | | Level of Course | First Cycle | | Status | Compulsory | | Department | DEPARTMENT of MOLECULAR BIOLOGY and GENETICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Dr. Öğr. Üyesi Uğur UZUNER | | Co-Lecturer | | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | To raise awareness in students about the biological microorganisms that play a role in the production of high value-added products in industrial biotechnology, and the development of these microorganisms at a level that can meet the needs of the industry, and the existing technologies to increase the amount of unit product. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Learns current trends in industrial biotechnology | 2,3 | | | LO - 2 : | Gains the ability to decide on suitable production hosts in the production of value-added active ingredients. | 2,3 | | | LO - 3 : | Improves awareness of metabolic engineering approaches | 2,3 | | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Introduction to Industrial Biotechnology: Fields of Study and Application/ Industrial Microorganisms. Microbial Growth Kinetics and Uses of Sterilization. Metabolism in Microorganisms. Fermentation Biotechnology and used bioreactor types. Selection of ideal production hosts for different production/product targets and processes followed during large-scale biotechnological productions, input and output cost calculation. Industrial primary and secondary metabolite producing microorganisms. Prokaryotic (Escherichia coli, Bacillus subtilis) and eukaryotic producer industrial hosts (Saccharomyces ceresivisae/Pichia pastoris, microalgae, fungi and mammalian cell culture). Examples of molecular and bioengineering activities on host microorganisms. Examples of biometabolite engineering... |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introduction to Industrial Biotechnology | | | Week 2 | Waste Water Treatment Processes | | | Week 3 | Bioremediation | | | Week 4 | Synthetic Biology | | | Week 5 | Metabolic Pathway Analysis at Genome Scale | | | Week 6 | Multipurpose Bacterial Cell Factories: E. coli as a host | | | Week 7 | Industrial microorganisms: Corynebacterium glutamicum | | | Week 8 | Midterm | | | Week 9 | Host Organism: Bacillus subtilis | | | Week 10 | Host Organism: Pseudomonas putida | | | Week 11 | Host Organism: Lactic acid bacteria | | | Week 12 | Host Organisms: Cyanobacteria vs Microalgae | | | Week 13 | Yeast cells as Production Hosts | | | Week 14 | As Production Hosts: Mammalian cells | | | Week 15 | Student Presentation | | | Week 16 | Final exam | | | |
| 1 | Christoph Wittman, James C. Liao. 2019 Industrial Biotechnolgy: Microorganisms. WİLEY-VCH Press | | | |
| 1 | M. J. Maites, N.L. Morgan, J.S.Rockey, G.Higton. Çev. Ed. Doç. Dr. İrfan Turan, ?Endüstriyel Mikrobiyolojiye Giriş?, Palme Yayıncılık, 2015. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | 07.05.2021 | 75 | 30 | | Presentation | 12 | 29.05.2021 | 75 | 20 | | End-of-term exam | 16 | 19.06.2021 | 75 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 3 | 14 | 42 | | Arasınav için hazırlık | 3 | 6 | 18 | | Arasınav | 3 | 1 | 3 | | Uygulama | 3 | 6 | 18 | | Ödev | 3 | 8 | 24 | | Proje | 3 | 6 | 18 | | Kısa sınav | 3 | 6 | 18 | | Dönem sonu sınavı için hazırlık | 3 | 1 | 3 | | Dönem sonu sınavı | 3 | 1 | 3 | | Total work load | | | 189 |
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