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| MBTL7091 | Epigenetics | 3+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of BIOTECHNOLOGY (INTERDISCIPLINARY) | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Doç. Dr. Selcen ÇELİK UZUNER | | Co-Lecturer | | | Language of instruction | | | Professional practise ( internship ) | None | | | | The aim of the course: | | The aim of the course is to understand how epigenetic changes occur both in normal developmental situations and in various anomalies where normal regulation is disrupted. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | Knows epigenetic mechanisms very well. | 1,2 | 1,5, | | PO - 2 : | Explains the epigenetic regulation mechanisms in germ cells and early embryogenesis. | 1,2 | 1,5, | | PO - 3 : | Refers to the role of epigenetics in post-embryogenesis and tissue-specific patterns. | 1,2 | 1,5, | | PO - 4 : | Describe describes the epigenetic profile of mitochondrial DNA genome. | 1,2 | 1,5, | | PO - 5 : | Knows the mechanisms of epigenetic regulation by RNA. | 1,2 | 1,5, | | PO - 6 : | Expresses how epigenetic mechanisms are dysregulated in many anomalies. | 1,2 | 1,5, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| This course covers the regulation of epigenetic mechanisms in development (early embryonic stage, post-embryogenesis period, gene/tissue specific expression, mitochondrial genome) and diseases (developmental disorders, neurodegenerative diseases, cancer, innate immunity against infections and metabolic diseases). |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Epigenetics - Introduction | | | Week 2 | Epigenetic regulation in germ cells | | | Week 3 | Epigenetic regulation in early embryogenesis | | | Week 4 | Epigenetic regulation in post-embryogenesis | | | Week 5 | The role of epigenetics regulation in tissue-specific regulation | | | Week 6 | Mitochondrial DNA epigenome | | | Week 7 | Mid-term exam | | | Week 8 | Epigenetic dysregulation in developmental diseases | | | Week 9 | Epigenetic dysregulation in neurodegenerative diseases | | | Week 10 | Epigenetic dysregulation in cancer | | | Week 11 | Epigenetic dysregulation in cancer (cont.) | | | Week 12 | The role of epigenetics in regulating innate immunity | | | Week 13 | Epigenetic regulation and epigenetic therapy in metabolic diseases | | | Week 14 | Final exam | | | Week 15 | | | | Week 16 | | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 7 | | 2 | 30 | | Presentation | 10 | | 1 | 20 | | End-of-term exam | 14 | | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 12 | 36 | | Total work load | | | 36 |
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