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| MBTL7030 | Prokaryote Molecular Biology and Synthetic Biology | 3+0+0 | ECTS:7.5 | | Year / Semester | Fall Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of BIOTECHNOLOGY (INTERDISCIPLINARY) | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Prof. Dr. Ali Osman BELDÜZ | | Co-Lecturer | . | | Language of instruction | | | Professional practise ( internship ) | None | | | | The aim of the course: | | The student will acquire fundamental knowledge of prokaryot molecular biology and physiology at an advanced level. The objective of the course is to provide an understanding of the physiology of the microbial cell and how it can be manipulated. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | To understand the synthetic biology approach | 2,5,8,9 | 1,3,5,6, | | PO - 2 : | To understand studies of mimicking biological systems | 2,5,8,9 | 1,3,5,6, | | PO - 3 : | Understanding the modification of systems biology | 2,5,8,9 | 1,3,5,6, | | PO - 4 : | Understanding the importance of synthetic biology | 2,5,8,9 | 1,3,5,6, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Gene expression and regulation, Growth and Bioenergetics, Coordination and regulation of microbial metabolism, Cell differentiation, Cell communication and interactions, Secondary metabolism, Genetic circuits, Design, construction and expression of synthetic pathways, Genetic engineering techniques and tool boxes, Synthetic genomes and gene editing, Omics technologies (Genome and transcriptomics;Proteomics;Metabolomics, fluxomics and lipid |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Gene expression and regulation | | | Week 2 | Growth and Bioenergetics | | | Week 3 | Coordination and regulation of microbial metabolism | | | Week 4 | Cell differentiation | | | Week 5 | Cell communication and interactions | | | Week 6 | Secondary metabolism | | | Week 7 | Genetic circuits | | | Week 8 | Design, construction and expression of synthetic pathways | | | Week 9 | Mid-term exam | | | Week 10 | Genetic engineering techniques and tool boxes | | | Week 11 | Synthetic genomes and gene editing | | | Week 12 | Genomics | | | Week 13 | Transcriptomics | | | Week 14 | Proteomics | | | Week 15 | Metabolomics | | | Week 16 | Final Exam | | | |
| 1 | Synthetic biology : a primer / [edited by] Paul Simon Freemont, Richard I. Kitney. Editors [2012].
ISBN 978-1-78326-878-8 (hardcover : alk. paper) -- ISBN 978-1-78326-879-5 (pbk. : alk. paper)
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| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 15/11/2021 | 1 | 30 | | Presentation | 8 | 25/11/2021 | 1 | 10 | | Homework/Assignment/Term-paper | 11 | 11/12/2021 | 1 | 10 | | End-of-term exam | 16 | 15/01/2022 | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 5 | 14 | 70 | | Laboratuar çalışması | 0 | 0 | 0 | | Arasınav için hazırlık | 6 | 7 | 42 | | Arasınav | 2 | 1 | 2 | | Uygulama | 0 | 0 | 0 | | Klinik Uygulama | 0 | 0 | 0 | | Ödev | 18 | 1 | 18 | | Proje | 0 | 0 | 0 | | Kısa sınav | 1 | 7 | 7 | | Dönem sonu sınavı için hazırlık | 6 | 7 | 42 | | Dönem sonu sınavı | 2 | 1 | 2 | | Total work load | | | 225 |
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