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| TMIK611 | Bacterial Genetics | 2+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of MEDICAL BIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face, Lab work , Practical | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | -- | | Co-Lecturer | Asst. Prof. Dr. C. Kurtuluş BURUK | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Include basic knowledge of bacterial genetics and its applications, and future directions. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | describe the terminology on bacterial genetic. | 1 | 1,6 | | PO - 2 : | identify the sorts of mutasyon | 1 | 1,6 | | PO - 3 : | apply various technics in microbial genetics. | 1 | 1,6 | | PO - 4 : | know types of recombination | 1,3,4,5,6,7,8 | 1,6 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Genetical elements of a bacterial cell, Replication mechanisms of genetic materials, Gene expression, Recombination mechanisms of bacteria, Principles of recombinant DNA technology and its applications.
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Genetic elements of a bacterial cell (genomic DNA, bacteriophages, plasmids, transpozons) | | | Week 2 | Mechanisms of Bacterial Replication and relationship between replicaton and proliferation | | | Week 3 | Gene expression (Transcription, translation) and regulation of gene expression, operons | | | Week 4 | Restriction Endonucleases | | | Week 5 | Recombination Mechanisms in Bacteria (Transformation, Conjucation, Transduction) | | | Week 6 | Mutations and Mutagens, and DNA repair mechanisms of Bacteria | | | Week 7 | Application areas of Manuplation of Bacterial Genetics in Medicine, Industry and others. | | | Week 8 | Mid-term exam | | | Week 9 | Recombinant DNA Technology and its Applications | | | Week 10 | Basic Technics of Recombinant DNA Technology | | | Week 11 | DNA sequencing | | | Week 12 | Assessment of Homework | | | Week 13 | Cloning strategies and Vectors | | | Week 14 | Restriction and recombination of DNA molecules, Selection and visualisation of recombinant strains | | | Week 16 | End-of-term exam | | | |
| 1 | Click B.R. and Pasternak J.J. 2003; Molecular Biotechnology: Principles and Applications of Recombinant DNA, ASM Press, Washington, D.C. | | | |
| 1 | Persing, D. H., Tenover, F. C., Versalovic, J., Tang YiWei, Unger, E. R., Relman, D. A., White, T. J. 2006; Molecular microbiology: diagnostic principles and practice, ASM Press, Washington, D.C. Çevirisi: Tekeli A. ve Ustaçelebi Ş. (çeviri editörleri) 2006; Moleküler Mikrobiyoloji: Tanı Prensipleri ve Uygulamalar, Palme Yayıncılık, Ankara. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | | 1 | 30 | | Homework/Assignment/Term-paper | 12 | | 1 | 20 | | End-of-term exam | 17 | | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 13 | 26 | | Sınıf dışı çalışma | 2 | 16 | 32 | | Laboratuar çalışması | 3 | 15 | 45 | | Arasınav için hazırlık | 1 | 7 | 7 | | Arasınav | 1 | 1 | 1 | | Uygulama | 1 | 10 | 10 | | Klinik Uygulama | 0 | 0 | 0 | | Ödev | 2 | 12 | 24 | | Proje | 0 | 0 | 0 | | Kısa sınav | 0 | 0 | 0 | | Dönem sonu sınavı için hazırlık | 10 | 1 | 10 | | Dönem sonu sınavı | 1 | 1 | 1 | | Diğer 1 | 0 | 0 | 0 | | Diğer 2 | 0 | 0 | 0 | | Total work load | | | 156 |
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