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| TBI6040 | Genetic Eng. and Gene Therapy | 2+2+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of MEDICAL BIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face | | Contact Hours | 14 weeks - 2 hours of lectures and 2 hours of practicals per week | | Lecturer | Prof. Dr. Ersan KALAY | | Co-Lecturer | None | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Basic scientific approach to gene therapy. Methods and strategies in gene therapy |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | describe the recent threatment application of genetic disease. | 8,9 | 1,3 | | PO - 2 : | describe the applications of gene therapy. | 10 | 1,3 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| History of genetic engineering. General principle of gene therapy. Gene engineering and basic research. Application models. Application of gene therapy Viral methods in gene transfer. Non-viral methods in gene transfer. Products of genetic engineering.
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Bıotechnology and bıoengineering | | | Week 2 | Recombinant DNA technology | | | Week 3 | Procedure on recombinant DNA technology | | | Week 4 | Procedure on recombinant DNA technology- DNA isolation | | | Week 5 | Procedure on recombinant DNA technology- DNA fragmentation | | | Week 6 | Vectors | | | Week 7 | İnserting a DNA sample into plasmid | | | Week 8 | Mid-term exam | | | Week 9 | Cloning | | | Week 10 | hybridization methods | | | Week 11 | hybridization methods | | | Week 12 | Homework | | | Week 13 | Recombinant DNA technology and practice into medicine | | | Week 14 | Gene therapy
Practice and products | | | Week 16 | A written end-of-term exam | | | |
| 1 | SU. Rosta, BD. Carbonare, C.Manzoni, S. Ryser. Genetic Engineering. F. Hofmann-La- Roche Ltd, Basel. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | | 2 | 30 | | Homework/Assignment/Term-paper | 12 | | 2 | 20 | | End-of-term exam | 16 | | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 2 | 14 | 28 | | Arasınav için hazırlık | 1 | 14 | 14 | | Arasınav | 2 | 1 | 2 | | Ödev | 2 | 14 | 28 | | Dönem sonu sınavı için hazırlık | 1 | 14 | 14 | | Dönem sonu sınavı | 2 | 1 | 2 | | Total work load | | | 130 |
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