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| TBI6023 | Molecular Biology and Genetics of Cancer | 2+0+2 | ECTS:7.5 | | Year / Semester | Fall Semester | | Level of Course | Third Cycle | | Status | Compulsory | | Department | DEPARTMENT of MEDICAL BIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face | | Contact Hours | 14 weeks - 2 hours of lectures and 2 hours of laboratory per week | | Lecturer | Prof. Dr. Figen CELEP EYÜBOĞLU | | Co-Lecturer | None | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | The aim of this cours is to provide information to studends about following subjects:
1. Cell cycle control
2. Cell signaling system,
3. Oncogene and oncogene activation
4. Carcinogenesis |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | explain cell signalling system. | 20 | 1 | | PO - 2 : | explain the cell cycle. | 3,20 | 1 | | PO - 3 : | describe the functions of proto-oncogenes, tumor supressor genes and DNA repair genes. | 3,20 | 1 | | PO - 4 : | describe the general properties of the cancer cells. | 28 | 3 | | PO - 5 : | explain carsinogenesis. | 23,29 | 1 | | PO - 6 : | explain carsinogens | 23 | 1 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| 1. Cell signaling system
2. Intracellular signal transduction
3. Genetic bases carcinogenesis
4. Proto-oncogene
5. Oncogenes
6. Tumor suppressor genes
7. DNA damage response genes
8. Cancer and DNA viruses
9. Cancer and RNA viruses
10.Characteristic features of cancer cells
11. Chemical carcinogenesis
12. Carcinogenesis and epigenetic |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Cell signaling system | | | Week 2 | Cell signaling syst | | | Week 3 | Intracellular signal transduction | | | Week 4 | Genetic bases carcinogenesis | | | Week 5 | Proto-oncogenes | | | Week 6 | Oncogenes | | | Week 7 | Tumor suppressor genes | | | Week 8 | Mid-term exam | | | Week 9 | DNA damage response genes | | | Week 10 | Cancer and DNA viruses | | | Week 11 | Cancer and RNA viruses | | | Week 12 | Characteristic features of cancer cells | | | Week 13 | Chemical carcinogenesis | | | Week 14 | Carcinogenesis and epigenetic | | | Week 16 | End-of-term exam | | | |
| 1 | Cooper, Geoffrey M. 2000; The Cell - A Molecular Approach Sunderland (MA): Sinauer Associates, Inc. | | | 2 | Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. 2002 ; Molecular Biology of the Cell. Fourth edition. Garland Science, New Yourk | | | |
| 1 | Darnel J, Lodish H, Baltimor D. 1990; Molecular Cell Biology. Scientific American Books. W.H. freeman and Company. New York | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 7 | | | 30 | | Homework/Assignment/Term-paper | 12 | | | 20 | | End-of-term exam | 16 | | | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 12 | 24 | | Sınıf dışı çalışma | 6 | 12 | 72 | | Laboratuar çalışması | 2 | 10 | 20 | | Arasınav için hazırlık | 6 | 7 | 42 | | Arasınav | 3 | 1 | 3 | | Uygulama | 0 | 0 | 0 | | Klinik Uygulama | 0 | 0 | 0 | | Ödev | 5 | 5 | 25 | | Proje | 0 | 0 | 0 | | Kısa sınav | 0 | 0 | 0 | | Dönem sonu sınavı için hazırlık | 6 | 6 | 36 | | Dönem sonu sınavı | 3 | 1 | 3 | | Diğer 1 | 0 | 0 | 0 | | Diğer 2 | 0 | 0 | 0 | | Total work load | | | 225 |
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