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| TBI6032 | Cell Signalling Systems | 2+0+2 | ECTS:7.5 | | Year / Semester | Fall Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of MEDICAL BIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face | | Contact Hours | 14 weeks - 2 hours of lectures and 2 hours of laboratory per week | | Lecturer | Dr. Öğr. Üyesi Bayram TORAMAN | | Co-Lecturer | | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | This course aims to provide students with a general understanding of cell communication principles, signaling mechanisms and signaling-disease relationships |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | understand the basic components of cell communication | 5 | 1 | | PO - 2 : | explain cell-cell signal transduction types | 5 | 1,3 | | PO - 3 : | describe protein-protein, ligand-receptor interactions and dissociation constant | 3,5,20 | 1,3 | | PO - 4 : | understand proteins used in cell signaling and their allosteric control mechanisms | | 1,5 | | PO - 5 : | describe the signaling cascades and their mechanisms of action | 20 | 1,5 | | PO - 6 : | understand post-translational modifications and their role in signaling | 20 | 1,4 | | PO - 7 : | explain the modular architecture and evolution of signal proteins | 5 | | | PO - 8 : | discuss secondary messengers and their use in signaling | | | | PO - 9 : | describe the mechanisms of termination and adaptation of signals | | | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| 1. Introduction to cell signaling
2. Cells have to pick up a wide variety of signals and give the best response
3. Basic components of cell communication
4. Types of cell-cell signal transduction
5. Cell surface receptors
6. G-protein signaling
7. Enzymes that regulate G-protein signaling
8. Protein-protein, ligand-receptor interactions and dissociation constant
9. Enzymes (proteins) used in cell signaling and allosteric control mechanisms
10. Signaling cascades and mechanisms
11. Post-translational modifications and signaling
12. Membranes, lipids and lipid modifying enzymes
13. Modular architecture and evolution of signal proteins
14. Second messengers and signaling
15. Signal termination mechanisms and adaptation |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introduction to cell signaling | | | Week 2 | Extracellular signal molecules | | | Week 3 | Cells have to pick up a wide variety of signals and give the best response | | | Week 4 | Basic components of cell communication
Types of cell-cell signal transduction
| | | Week 5 | Cell surface receptors | | | Week 6 | G-protein signaling
Enzymes that regulate G-protein signaling
| | | Week 7 | Protein-protein, ligand-receptor interactions and dissociation constant | | | Week 8 | Mid-term exam | | | Week 9 | proteins used in cell signaling and allosteric control mechanisms | | | Week 10 | Signaling cascades and mechanisms | | | Week 11 | Post-translational modifications and signaling | | | Week 12 | Membranes, lipids and lipid modifying enzymes | | | Week 13 | Modular architecture and evolution of signal proteins | | | Week 14 | Second messengers and signaling | | | Week 15 | Signal termination mechanisms and adaptation | | | Week 16 | End-of-term exam | | | |
| 1 | Wendell Lim, Bruce Mayer, Tony Pawson. 2015;Cell Signaling: principles and mechanisms, Garland Science. | | | 2 | Friedrich Marks, Ursula Klingmüller, Karin Müller-Decker. 2009; Cellular Signal Processing. An Introduction to the Molecular Mechanisms of Signal Transduction, Garland Science. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | | 2 | 30 | | Homework/Assignment/Term-paper | 12 | | 3 | 20 | | End-of-term exam | 16 | | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 14 | 28 | | Sınıf dışı çalışma | 0 | 0 | 0 | | Laboratuar çalışması | 4 | 10 | 40 | | Arasınav için hazırlık | 0 | 0 | 0 | | Arasınav | 3 | 1 | 3 | | Uygulama | 0 | 0 | 0 | | Klinik Uygulama | 0 | 0 | 0 | | Ödev | 2 | 4 | 8 | | Proje | 0 | 0 | 0 | | Kısa sınav | 0 | 0 | 0 | | Dönem sonu sınavı için hazırlık | 0 | 0 | 0 | | Dönem sonu sınavı | 3 | 1 | 3 | | Diğer 1 | 0 | 0 | 0 | | Diğer 2 | 0 | 0 | 0 | | Total work load | | | 82 |
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