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| TBI5052 | Nuc. Acids and Gene Regulation | 2+0+2 | ECTS:7.5 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of MEDICAL BIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face, Lab work | | Contact Hours | 14 weeks - 2 hours of lectures and 2 hours of laboratory per week | | Lecturer | Prof. Dr. Ersan KALAY | | Co-Lecturer | | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Understanding of structure of the nücleic acides, gene, gene expression, mutation, DNA repair and gene expression control. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | explain the molecular structure of the nücleic acides. | 1,5,6,7,17,18,19,22 | 1, 3 | | PO - 2 : | explain the molecular mechanism of DNA replication | 4,5 | 1 | | PO - 3 : | explain the organisation of human genom | 17 | 1 | | PO - 4 : | explain the type and function of the RNAs | 5 | 1 | | PO - 5 : | describe the gene expression. | 18 | 3 | | PO - 6 : | describe point mutation and point mutation types. | 19 | 1,3 | | PO - 7 : | talk about DNA repair mechanisms. | 20 | 1,3 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| The aim of this cours is to provide information to studends about following subjects; 1. Discovery of the hereditary materials (nucleic asides) 2. Molecular structure and organisation of DNA 3. Replication of DNA 4. Transcription (RNA synthesis) 5. Translation (Protein synthesis) 6. Types of RNA. Moleculer structure and function of RNAs 7. Regulation of genes function (operon concept) 8. Mutations 9. Mutation mechanisms. 10. DNA repair. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Discovery of the hereditary materials (nucleic asides) | | | Week 2 | Molecular structure and organisation of DNA | | | Week 3 | Molecular structure and organisation of DNA | | | Week 4 | Replication of DNA | | | Week 5 | Replication of DNA | | | Week 6 | Transcription (RNA synthesis) | | | Week 7 | Transcription (RNA synthesis) | | | Week 8 | Mid-term exam | | | Week 9 | Translation (Protein synthesis) | | | Week 10 | Types of RNA, moleculer structure and function of RNAs
| | | Week 11 | Types of RNA, Moleculer structure and function of RNAs | | | Week 12 | micro RNA | | | Week 13 | Regulation of genes function (operon concept) | | | Week 14 | Mutation,mutation mechanisms and DNA repair | | | Week 16 | End-of-term exam
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| 1 | Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. 2002 ; Molecular Biology of the Cell. Fourth edition. Garland Science, New Yourk | | | |
| 1 | Cooper, Geoffrey M. 2000; The Cell - A Molecular Approach Sunderland (MA): Sinauer Associates, Inc. | | | 2 | Darnel J, Lodish H, Baltimor D. 1990; Molecular Cell Biology. Scientific American Books. W.H. freeman and Company. New York | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | | 1,5 | 30 | | Homework/Assignment/Term-paper | 12 | | 4 | 20 | | End-of-term exam | 16 | | 1,5 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 4 | 14 | 56 | | Sınıf dışı çalışma | 2 | 14 | 28 | | Arasınav için hazırlık | 16 | 2 | 32 | | Arasınav | 2 | 1 | 2 | | Dönem sonu sınavı için hazırlık | 32 | 1 | 32 | | Dönem sonu sınavı | 3 | 1 | 3 | | Total work load | | | 153 |
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