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| TBIO605 | Structure of Biolog.Membrane and Transport | 3+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of MEDICAL BIOCHEMISTRY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | -- | | Co-Lecturer | | | Language of instruction | | | Professional practise ( internship ) | None | | | | The aim of the course: | | The course aims to provide the students with a general knowledge on the structure and the functions of biological membranes and membrane transport systems. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | Discuss about the structure of membrane lipids | | | | PO - 2 : | Predict about the behaviour of the membrane proteins and lipids in membrane function | | 1,3 | | PO - 3 : | Discuss about the thermodynamics of membrane transport | | 1,3 | | PO - 4 : | Discuss on the types and functions of membrane transporters wit their medical examples | | | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| The composition of membranes: proteins and lipids
Fluid mosaic model
Freeze-fracture tecnique
Types of membrane proteins
Membrane dynamics
The functions of membranes
Membrane transport systems |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | General properties of biological membranes | | | Week 2 | Structure of membrane lipids | | | Week 3 | Behavior, contribution and functions of membrane lipids in membrane structure | | | Week 4 | Lipid asymmetry and mobility | | | Week 5 | The role of membrane lipids in cell signalization | | | Week 6 | Amino acids and protein structure, hydropathy plots. Classification of membrane proteins and their properties
| | | Week 7 | Amino acids and protein structure, hydropathy plots. Classification of membrane proteins and their properties | | | Week 8 | Midterm exam | | | Week 9 | Membrane Dynamics | | | Week 10 | Overview and Thermodynamics of Membrane Transport
| | | Week 11 | Passive-Mediated Transport
1- Ionophores
2- Porins
3- Ion channels
4- Aquaporins
5- Transport Proteins
| | | Week 12 | Passive-Mediated Transport
1- Ionophores
2- Porins
3- Ion channels
4- Aquaporins
5- Transport Proteins
| | | Week 13 | Active Transport and some important examples | | | Week 14 | Active Transport and some important examples | | | Week 16 | Final Exam | | | |
| 1 | Nelson, D.L., Cox, M.M., 2005, Lehninger Principles of Biochemistry, W.H. Freeman and Company. | | | 2 | Küfrevioğlu, Ö. İ., Keha, E. E., 2015, Biyokimya, Aktif Yaınevi.11.ed | | | 3 | Berg, J.M., Tymoczko, J.L., Stryer, L. 2002, Biochemistry, W.H. Freeman and Company. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | | 2 | 30 | | Homework/Assignment/Term-paper | 11 | | 3 | 20 | | End-of-term exam | 16 | | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 8 | 14 | 112 | | Laboratuar çalışması | 0 | 0 | 0 | | Arasınav için hazırlık | 10 | 1 | 10 | | Arasınav | 2 | 1 | 2 | | Uygulama | 0 | 0 | 0 | | Klinik Uygulama | 0 | 0 | 0 | | Ödev | 10 | 1 | 10 | | Proje | 0 | 0 | 0 | | Kısa sınav | 0 | 0 | 0 | | Dönem sonu sınavı için hazırlık | 12 | 1 | 12 | | Dönem sonu sınavı | 3 | 1 | 3 | | Diğer 1 | 0 | 0 | 0 | | Diğer 2 | 0 | 0 | 0 | | Total work load | | | 191 |
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