|
|
| TMIK531 | General Immunology | 2+0+0 | ECTS:7.5 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Compulsory | | Department | DEPARTMENT of MEDICAL MICROBIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face, Group study | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Prof. Dr. Ali Osman KILIÇ | | Co-Lecturer | None | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Include presentation of innate and specific immunity in general. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | Describe the means of entry of pathogens to the body, including how they bypass the mechanical and chemical barriers to entry. Give examples from bacteria and viruses. | 1 | 3,5 | | PO - 2 : | Learn the roles of soluble molecules such as cytokines and chemokines as well as cells such as macrophages and neutropils phagocytes in defence in terms of innate response | 1 | 3 | | PO - 3 : | Describe the killing mechanisms exerted by macrophages and neutrophils | 1,4 | 3 | | PO - 4 : | Summarize the innate activation of complement, and review the functions of activated complement. | 1,4 | 3 | | PO - 5 : | Desribe antigens and antibodies | 1,4 | 1 | | PO - 6 : | Summarize the function of the major histocompatability complex. | 1,4 | 1 | | PO - 7 : | Describe how antibodies are generated by B-lymphocytes incuding mono- or polyclonality incuding the basic structure and function of an antibody | 1,4 | 1 | | PO - 8 : | Summarize the sequence of events of antibody-mediated immunity, including the effects of antigen?antibody complexes on pathogens. | 1,4 | 1 | | PO - 9 : | Describe the antigen presentation to cytotoxic T lymphocytes
Describe the sequence of events in cell-mediated immunity.
Describe the basis of immunological memory; contrast secondary and primaryimmune responses | 1,4 | 1 | | PO - 10 : | .? Describe the basis of immunological memory; contrast secondary and primaryimmune responses.
| 1,4 | 1 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| General presentation of immunologically related organ and tissues. Specific description of innate immunity including complements system, cytokines and kemokines; structural and organizational aspects of major histocompatibity antigens towards understanding the nature of specific immune response in relation to development of specific antibody against microbial antigens; development and significance of cellular cytotoxicity and its effector arms. |
| |
| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introduction to immune response; default system | | | Week 2 | Organization and organelles of the immune system
| | | Week 3 | Physical and chemical barriers constitutive immune responses
| | | Week 4 | The cellular arms of the non-specific immune response | | | Week 5 | Interactions between cells and microorganisms at the tissue level; PAMPs and PRRs
| | | Week 6 | Macrophage activation; release of cytokines and kemokines
| | | Week 7 | Proinflammatory cytokines | | | Week 8 | Mid-term exam | | | Week 9 | Extravasation of neutrophils and other immune cells
| | | Week 10 | Acute phase proteins: positive (CRP, MBL etc) and negative (albumin etc) acute phase proteins
| | | Week 11 | Microbial killing mechanisms exerted by macrophages and neutrophils
| | | Week 12 | Homework | | | Week 13 | Spesific immune response: T and B lymphocytes | | | Week 14 | Major histocompatibility antigens and their significans in specific immune response | | | Week 15 | Antigen presenting cells; antigen capture, processing and presentation of antigens by antigen presenting cells including macrophages and dendritic cells
| | | Week 16 | End-of-term exam | | | |
| 1 | Temel İmmunoloji: Prof.Dr.Yusuf Özbal. 2nd Edition. 2000. | | | 2 | Şemsettin Ustacelebi (editor), Temel ve Klinik Mikrobiyoloji,1999, Güneş Kitapevi. | | | |
| 1 | İmmunoloji: Kaya Kılıçturgay. 2003. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8
12 | 13/11/2009
13/12/2009 | 60
60 | 30 | | Homework/Assignment/Term-paper | 6
12 | | | 20 | | End-of-term exam | 17 | 19/01/210 | | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 16 | 32 | | Sınıf dışı çalışma | 2 | 16 | 32 | | Arasınav için hazırlık | 6 | 2 | 12 | | Arasınav | 2 | 2 | 4 | | Ödev | 6 | 2 | 12 | | Proje | 2 | 2 | 4 | | Kısa sınav | 1 | 2 | 2 | | Dönem sonu sınavı için hazırlık | 20 | 1 | 20 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 119 |
|