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| TMIK522 | General Virology | 2+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Second Cycle | | Status | Compulsory | | Department | DEPARTMENT of MEDICAL MICROBIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Prof. Dr. Ali Osman KILIÇ | | Co-Lecturer | None | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Include presentation of medically important viruses icluding basic structures and means of cultivation and characterization |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | Be able to talk about the history of virology | 1 | 3 | | PO - 2 : | Describe physical and chemical structure of viruses and describe the classification means of viruses | 1 | 3 | | PO - 3 : | Describe the cell infection cyle of enveloped and non-enveloped (naked) and viruses | 1 | 3 | | PO - 4 : | Summarize the cell infection cyle of picornaviruses | 1 | 3 | | PO - 5 : | Summarize the cell infection cycle of herpes viruses and retroviruses | 1 | 3 | | PO - 6 : | Describe how viruses are cultivated | 1,4 | 3 | | PO - 7 : | Summarize the cell culture technology including describing how primary fibroblast cell culture is established using embryonated eggs | 1,4 | 3,4 | | PO - 8 : | Describe the cytopatic effect (cpe) and give spesific examples of cpe for individual medically important viruses in cell culture | 1,4 | 3,4 | | PO - 9 : | Summarize and describe the quantitation techniques for viruses | 1,2 | 3 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Include to provide students with an ability to: (i) understand the nature of viruses, the principles of virus structure and the basic criteria used for classification of animal viruses; (ii) replication strategies of animal viruses; (iii) demonstrate knowledge and understanding of the mechanisms of viral pathogenesis and the outcomes of viral infections, including persistence, of selected viruses; (iv) demonstrate knowledge of laboratory diagnosis of viral diseases (vi) carry out a range of advanced skills and laboratory techniques, including the growth and quantitation of some viruses. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Brief history of virology; major advances in the discovery of agents responsible for medicinallu important viruses | | | Week 2 | General morphology of viruses; classification based on genetic material and enveloped or unenvolopment state | | | Week 3 | Classification of viruses according to their nucleic acid content | | | Week 4 | Cellular infection by viruses; virus attachment proteins, adsorption, entry | | | Week 5 | Cellular infection by viruses; release of kapsid, the fate of the nucleic acid | | | Week 6 | Cellular infection by viruses; biosynthesis | | | Week 7 | Cellular infection by viruses; replication strategy of negative/positive sense RNA viruses | | | Week 8 | Mid-term exam | | | Week 9 | Cellular infection by viruses; replication strategy of ambisense RNA viruses; replication of DNA viruses | | | Week 10 | replication of influenza and polioviruses | | | Week 11 | Replication of herpes simplex virus | | | Week 12 | Replication of AIDS virus; significans of reverse transcriptase | | | Week 13 | Cultivation of viruses; culture of viruses in embryonated eggs | | | Week 14 | Cultivation of viruses; culture of viruses in cell cultures; basic principles of cell culture technology | | | Week 15 | Quantitation of viruses; cytopathic effect, electrom microscopy, hemagglutination | | | Week 16 | End-of-term exam | | | |
| 1 | Şemsettin Ustacelebi (editor), Temel ve Klinik Mikrobiyoloji,1999, Güneş Kitapevi. | | | 2 | A. Tevfik Cengiz (Editör), Mikrobiyoloji, 2004, Güneş Kitapevi, Güneş Kitapevi. | | | |
| 1 | http://pathmicro.med.sc.edu/book/virol-sta.htmhttp://www.uct.ac.za/depts/mmi/stannard/linda.html | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | 11/11/2009 | 60 | 30 | | Laboratory exam | 8 | 12/11/2009 | 60 | 20 | | Presentation | 10 | 13/11/2009 | 30 | | | Homework/Assignment/Term-paper | 12 | 14/11/2009 | | | | End-of-term exam | 17 | 19/11/2009 | 60 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 16 | 32 | | Sınıf dışı çalışma | 2 | 16 | 32 | | Laboratuar çalışması | 1 | 5 | 5 | | Arasınav için hazırlık | 10 | 2 | 20 | | Arasınav | 1 | 2 | 2 | | Ödev | 6 | 2 | 12 | | Proje | 2 | 2 | 4 | | Kısa sınav | 2 | 2 | 4 | | Dönem sonu sınavı için hazırlık | 20 | 2 | 40 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 152 |
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