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| KIM7200 | Binding Metal-Ion and Complexes Biomolecule | 3+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of CHEMISTRY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face, Group study | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | -- | | Co-Lecturer | prof.dr.Serdar KARABÖCEK | | Language of instruction | Turkish | | Professional practise ( internship ) | 8 Day professional practise | | | | The aim of the course: | | Explain biological molecules effects of metal-ion and metal complexesExplain to nucleic asids of metal and metal-complexes |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | explain biological molecules effects of metal-ion and metal complexes | 1,2,3 | 1,3 | | PO - 2 : | explain to nucleic acids of metal and metal-complexes binding | 1,2,3 | 1,3 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Selection and insertion of metal Ions for protein sites I) thermodynamic control, ii) Kinetic control, iii) bioavailability, Preservation of electroneutrality i) Mononuclear sites, ii) polynuclear sites Metal-ion and metal-complex binding to nucleic acids Biopolymer-promoted metal-ligand interactions i) ferrochelates, ii) DNA promoted reaction chemistry hemertrin and hemocyanine i) oxy- and deoxy- hemertrine ii) Oxy- ve deoxy-hemocyanine |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Selection and insertion of metal Ions for protein sites | | | Week 2 | Thermodynamic control | | | Week 3 | Kinetic control | | | Week 4 | bioavailability | | | Week 5 | Preservation of electroneutrality | | | Week 6 | Mononuclear sites | | | Week 7 | polynuclear sites | | | Week 8 | Mid-term exam | | | Week 9 | Metal-ion and metal-complex binding to nucleic acids | | | Week 10 | Biopolymer-promoted metal-ligand interactions | | | Week 11 | ferrochelates, DNA promoted reaction chemistry | | | Week 12 | homework | | | Week 13 | hemertrin and hemocyanine | | | Week 14 | oxy- and deoxy- hemertrine , Oxy- ve deoxy-hemocyanine | | | Week 15 | End-of-term exam | | | |
| 1 | Lippard,S. J., Berg, J. M.,Valley,M.1994; PRINCIPLES of Bioinorganic Chemistry University Science Books, California,USA. | | | |
| 1 | Fenton, D. E. 2005; Biocoordination Chemistry, Oxford University Press, UK. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | 03/04/2010 | 2 | 30 | | In-term studies (second mid-term exam) | 12 | 05/06/2010 | 2 | 20 | | End-of-term exam | 17 | 01/07/2010 | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 5 | 13 | 65 | | Arasınav için hazırlık | 10 | 2 | 20 | | Arasınav | 2 | 1 | 2 | | Ödev | 5 | 12 | 60 | | Dönem sonu sınavı için hazırlık | 5 | 2 | 10 | | Dönem sonu sınavı | 2 | 1 | 2 | | Total work load | | | 201 |
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