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| KIM7241 | Bioactive Fused Heterocyclic Compounds | 3+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of CHEMISTRY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face, Group study | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | -- | | Co-Lecturer | None | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | To give information on the synthesis and bioactivities of the compounds incorporating fused heterocyclic ring systems.
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| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | know the synthesis of bioactive compounds incorporating fused heterocyclic rings | 1,2,3 | 1,3 | | PO - 2 : | know the releationship between structure-activity | 1,2,3 | 1,3 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Triazolotriazines; 1, 2, 4-triazolo mercapto and aminonitriles; triazolotriazoles; 1, 3, 4, thiadiazoles; triazolooxadiazoles; triazolothiazoles, oxazolidinones, thiazolidinones |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Structures, properties and synthesis of triazoles and triazines | | | Week 2 | Synthesis, properties and bioactivities of triazolotriazines | | | Week 3 | Synthesis and bioactivities of 1,2,4-triazolo mercapto and aminonitriles | | | Week 4 | Synthesis of triazolotriazoles and their bioactivities | | | Week 5 | Synthesis of 1,3,4-thiadiazoles, the drugs containing this heterocyclic ring and their bioactivities | | | Week 6 | Synthesis of 1,2,4-thiadiazoles, the drugs containing this heterocyclic ring and their bioactivities | | | Week 7 | The drugs conyaining triazole ring and theirsynthesis methods | | | Week 8 | Oxadiazoles, their properties, synthesis methods, bioctive oxadiazole compounds | | | Week 9 | Mid-term exam | | | Week 10 | Synthesis of triazolooxadiazoles and their bioactivities | | | Week 11 | The bioactive compounds obtained using phenacyl bromides | | | Week 12 | Bioactive compounds obtained using hydrazides | | | Week 13 | The bioactive compounds obtained using carbothioamides | | | Week 14 | Bioactive pyrazine derivatives | | | Week 15 | Bioactive oxazolidinones and their synthesis methods | | | Week 16 | End-of-term exam | | | |
| 1 | Silverman, R. B., 2003, The Organic Chemistry of Drug Design and Drug Action, New York. | | | |
| 1 | Palaska, E., Bilgin, A. A., Şafak C.ve diğerleri, 2004, Farmasötik Kimya, Hacettepe Üniversitesi Yayınları, Ankara. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 24/11/2013 | 2 | 30 | | In-term studies (second mid-term exam) | 10 | 05.01.2014 | 2 | 20 | | End-of-term exam | 17 | 18/01/2014 | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 5 | 14 | 70 | | Arasınav için hazırlık | 10 | 1 | 10 | | Arasınav | 2 | 1 | 2 | | Ödev | 5 | 12 | 60 | | Dönem sonu sınavı için hazırlık | 14 | 1 | 14 | | Dönem sonu sınavı | 2 | 1 | 2 | | Total work load | | | 200 |
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