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| KIM7321 | Synthesis With Phase Transfer Catalysts | 3+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of CHEMISTRY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | -- | | Co-Lecturer | Doç. Dr. Neslihan Demirbaş | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Preparation of phase catalysis.Mechanism of PTC reaction, their advantages and applications. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | Know what phase transfer catalyst is. | 1,2,3 | 1 | | PO - 2 : | Know use of phase transfer catalist in organic synthesis. | 1,2,3 | 1 | | PO - 3 : | Know the mechanisms of PTC reactions. | 1,2,3 | 1 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Mechanisms of PTC reaction, types of phase transfer catalysts, preparation of phase transfer catalysts, synthesis of nitriles from alkyl halides, benzoil cyanides from benzoil chlorides, azides from alkyl halides, alkyl nitrates, thiocyanates, cyanides and p-toluene sulphonates from alkyl halides, synthesis of aryl ethers and thioethers, reactions of esterification, diazotransfer, elimination reactions, wittig-horner reaction, benzoin condenzation. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introduction. The nature of SN2 reactions. | | | Week 2 | Definitionof phase transfer catalysts.
| | | Week 3 | Mechanisms of phase transfer catalysts. | | | Week 4 | Types of phase transfer catalysts. | | | Week 5 | Preperation of phase transfer catalysts. Quaternary Salts. Exchanceof anions onthe quaternary salts. | | | Week 6 | Macrocyclic eters as phase transfer catalysts. Tetrahexyl ammonium bromide.Hexadecyl tributyl phosphonium bromide. | | | Week 7 | Tetrahexyl ammonium hidrogen suphate. Tetrabutyl ammonium hidrogen suphate. Benzyl triethylammonium chloride. | | | Week 8 | Mid-term exam | | | Week 9 | Applications of phase transfer catalysis in organic synthesis. Nitriles from alkyl halides. Benzoyl cyanides from benzoyl chlorides. | | | Week 10 | The synthesis of alchole from alkyl halides. Synthesis of azides. Synthesis of p-toluen sulphonates, alkyl nitrates, thiocynates and cyanides from alkyl halides. | | | Week 11 | Esterification. Diazo transfer by phase trasfer catalyst. Dihalocarbenes. Elimination reactions. Alkylations. | | | Week 12 | Benzoin condenzation. Michael reaction. Williamson ether synthesis. The Wittig reaction. The Wittig-Horner reaction | | | Week 13 | Sulfur ylides, heterocyclic compounds, beta lactams. | | | Week 14 | Oxidation, reduction. | | | Week 15 | Miscellanous reactions by phase transfer catalist. | | | Week 16 | End-of-term exam | | | |
| 1 | Ahluwalia, V.K. and Aggarwal, R. 2001; Organic Synthesis Special Techniques, Alpha Science International Ltd. UK | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | 04/04/2016 | 2 | 30 | | In-term studies (second mid-term exam) | 13 | 05/05/2016 | 2 | 20 | | End-of-term exam | 16 | 25/05/2016 | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | | | | |
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