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| KIM7510 | Nucleotide and Nucleic Acid Biochemistry | 3+0+0 | ECTS:7.5 | | Year / Semester | Fall Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of CHEMISTRY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | -- | | Co-Lecturer | None | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Understanding the structure, function and metabolism of nucleic acids |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | will learn the structures and functions of nucleic acids and will be able to present structure-function relationship in nucleic acids
| 1,2 | 1 | | PO - 2 : | will be able to explain the copying and transfer of genetic information
| 1,2 | 1 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Nucleic acid metabolism, Synthesis of purine nucleotides, Synthesis of pyrimidine nucleotides, Purine catabolism, Pyrimidine catabolism, Chemical structure of nucleotides, Primary, secondary and tertiary structure of nucleic acids, Function of nucleic acids in the cell, Nucleic acid mutations and investigation of its damage to the cell, Nucleic acids and hormones. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Nucleic acid metabolism | | | Week 2 | Synthesis of purine nucleotides | | | Week 3 | Synthesis of pyrimidine nucleotides | | | Week 4 | Purine catabolism | | | Week 5 | Pyrimidine catabolism | | | Week 6 | Chemical structure of nucleotides | | | Week 7 | Primary and secondary structure of nucleic acids | | | Week 8 | Mid-term exam | | | Week 9 | Tertiary structure of nucleic acids | | | Week 10 | Function of nucleic acids in the cell | | | Week 11 | Investigation of nucleic acid mutations | | | Week 12 | Investigation of nucleic acid mutation causes | | | Week 13 | 2nd midterm exam | | | Week 14 | Investigation of nucleic acid mutations damage to the cell | | | Week 15 | Nucleic acids and hormones | | | Week 16 | End-of-term exam | | | |
| 1 | Nelson, D.L. ve Cox, M. M. (Çeviren; N. Kılıç) 2005; Lehninger Biyokimyanın İlkeleri, Palme Yayıncılık, Ankara. | | | |
| 1 | Horton, H.R. et al. 2006; Principles of Biochemistry, Fourth edition, Pearson Education International, New Jersey. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 11/11/2012 | 1,25 | 50 | | End-of-term exam | 16 | 09/01/2013 | 1,25 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 13 | 39 | | Sınıf dışı çalışma | 5 | 13 | 65 | | Arasınav için hazırlık | 10 | 2 | 20 | | Arasınav | 1.25 | 1 | 1.25 | | Ödev | 5 | 12 | 60 | | Kısa sınav | 1.25 | 1 | 1.25 | | Dönem sonu sınavı için hazırlık | 5 | 2 | 10 | | Dönem sonu sınavı | 1.25 | 1 | 1.25 | | Total work load | | | 197.75 |
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