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| ECZ4059 | Separation Techniques and Chromatography in Drug Analysis | 2+0+0 | ECTS:4 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Dr. Öğr. Üyesi Sercan YILDIRIM | | Co-Lecturer | | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | To teach the basics of separation techniques, especially chromatographic techniques used in drug analysis, as well as optimization approaches |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Have knowledge about the basics of chromatographic techniques and optimization processes. | 2,5,10 | 1, | | LO - 2 : | Understands the importance of chromatographic techniques in drug analysis. | 2,5,10 | 1, | | LO - 3 : | Learns to solve the problems encountered in chromatographic analysis from an analytical point of view. | 2,5,10 | 1, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| In this course, the history of separation techniques, general theory of chromatography, fundamentals and instrument design of different separation techniques (liquid chromatography, gas chromatography, capillary electrophoresis, supercritical fluid chromatography), and approaches to separation optimization will be taught. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | History of chromatographic techniques | | | Week 2 | Basic principles of chromatography | | | Week 3 | Chromatographic techniques based on separation mechanism | | | Week 4 | Basic chromatographic terms | | | Week 5 | Optimization of chromatographic separations | | | Week 6 | High performance liquid chromatography: Reservoirs, degassers and pumps | | | Week 7 | High performance liquid chromatography: Autosamplers and detectors | | | Week 8 | Column packing materials and stationary phases in liquid chromatography | | | Week 9 | Midterm Exam | | | Week 10 | Gas chromatography: Instrument modules and columns | | | Week 11 | Detectors and applications in gas chromatography | | | Week 12 | | | | Week 13 | Fundamentals of capillary electrophoresis | | | Week 14 | Supercritical fluid chromatography | | | Week 15 | Chromatographic method validation | | | Week 16 | Final Exam | | | |
| 1 | Harvey, D. (2000) Modern Analytical Chemistry. Boston, McGraw-Hill, Massachusetts | | | 2 | Lloyd R. Snyder, Joseph J. Kirkland, John W. Dolan (2010) Introduction to Modern Liquid Chromatography 3rd Edition | | | |
| 1 | G.D. Christian, P. Dasgupta, K. Schug (2013) Analytical Chemistry, 7th Edition: Seventh Edition, Wiley Global Education. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 11/2024 | 1 | 50 | | End-of-term exam | 16 | 1/2025 | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 14 | 28 | | Arasınav için hazırlık | 5 | 7 | 35 | | Arasınav | 1 | 1 | 1 | | Dönem sonu sınavı için hazırlık | 6 | 7 | 42 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 107 |
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