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| ECZ3026 | Pharmaceutical Chemistry Laboratory - II | 0+0+3 | ECTS:2 | | Year / Semester | Spring Semester | | Level of Course | Second Cycle | | Status | Compulsory | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 3 hours of laboratory per week | | Lecturer | Dr. Öğr. Üyesi Hasan Erdinç SELLİTEPE | | Co-Lecturer | Assoc. Prof. İnci Selin Doğan, Asst. Prof. Sevda Türk | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | The aim of the course is to give theoretical knowledge and application examples about the separation and purification methods of drugs to the students. In addition, students are also working on pharmacopoeial analysis with the identification of metabolites of some drug molecules. Students who take this course are expected to gain theoretical and practical experience in controlling the separation and purity of the mixture in the laboratory |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Explains chromatography and determination of physicochemical parameters of drugs. | 1,2,5 | 1,4, | | LO - 2 : | Present information about the drug molecule. | 1,2,5 | 5, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Paper, thin layer, column and high pressure liquid chromatography techniques, and their applications in drug analysis. Separation of solid-solid and liquid-liquid mixtures. Determination of physical constants such as density, boiling and melting point, measurement of refraction index, determination of specific rotation. Determination of drug metabolites and pharmacopoeial analysis. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Chromatography and its fundamentals | | | Week 2 | Chromatography methods | | | Week 3 | Determination of molecular weight , density, melting point and boiling point, refractometry, polarimetry | | | Week 4 | Liquid density determination and separation of liquid-liquid mixtures | | | Week 5 | Determination of solid density and separation of solid mixture | | | Week 6 | Polarimetry and melting point determination | | | Week 7 | Refractometry and boiling point determination | | | Week 8 | Pharmacopoeia analysis (Distilled water + urea) | | | Week 9 | Midterm exam | | | Week 10 | Chromatography (amino acid determination) + Pharmacopoeia analysis (NaCl) assay | | | Week 11 | Drug metabolism | | | Week 12 | Column chromatography | | | Week 13 | Student presentations (Drug molecule) | | | Week 14 | Student presentations (Drug molecule) | | | Week 15 | Student presentations (Drug molecule) | | | Week 16 | Final exam | | | |
| 1 | Hart Craine Hart, Organik Kimya, (Çeviri ed. Tahsin Uyar, Palme Yayıncılık, 2005), Houghton Mifflin Company, 1995. | | | 2 | T. W. Graham Solomons, C. B. Fryhle, Organic Chemistry, 7th Ed., (Çeviri Editörleri: Gürol Okay, Yılmaz Yıldırır, Literatür Yayıncılık, 2002), John Wiley & Sons, Toronto, 2000. | | | 3 | Vogel A. ?A Textbook of Practical Organic Chemistry? London, 1970 | | | 4 | An Introduction to Medicinal Chemistry İngilizce Baskı Graham Patrick | | | 5 | Wilson and Gisvold?s Textbook of Organıc Medicinal and Pharmaceutical Chemistry. 12th Edition. | | | 6 | Akgün, H., Balkan, A., Bilgin, A.A., Çalış, Ü., Dalkara, S., Erdoğan, H., Erol Demir, D., Ertan, M.,Gökhan, N., Özkanlı, F., Palaska, E., Saraç, S. ve Şafak, C., Tozkoparan.B.: Farmasötik Kimya, Ankara, 2016 | | | 7 | Büyük Ölçekli ve Küçük Ölçekli Organik Kimya Deneyleri. Kenneth L. Williamson, Robert D. Minard, Katherine M. Masters PALME YAYINCILIK | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 15.04.2024 | 1 | 50 | | Presentation | 13
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15 | Mayıs | 0,25 | 5 | | End-of-term exam | 16 | 03.06.2024 | 2 | 45 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 6 | 12 | | Laboratuar çalışması | 3 | 8 | 24 | | Arasınav için hazırlık | 1 | 7 | 7 | | Arasınav | 1 | 1 | 1 | | Dönem sonu sınavı için hazırlık | 1 | 7 | 7 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 52 |
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