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| ECZ3024 | Pharmaceutical Chemistry - II | 2+0+0 | ECTS:3 | | Year / Semester | Spring Semester | | Level of Course | Second Cycle | | Status | Compulsory | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Doç. Dr. İnci Selin DOĞAN | | Co-Lecturer | asis prof Hasan Erdinç Sellitepe, asis prof Sevda Türk, research asis Ahmet Buğra Aksel | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | The aim of this course is; the basic properties of drugs acting on the autonomic nervous system and cardiovascular system, the mechanisms of action, structure-effect relationships, synthesis and biotransformation.
* Lab: The aim of the course is to give theoretical knowledge and application examples about the separation and purification methods of drugs to the students. In addition, students are also working on pharmacopoeial analysis with the identification of metabolites of some drug molecules. Students who take this course are expected to gain theoretical and practical experience in controlling the separation and purity of the mixture in the laboratory |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | analyse the structure-activity relationships of drugs acting on autonomous nervous system.
| 3,4,5,9 | 1,4,6, | | LO - 2 : | debate the structure-activity relationships and chemical analyses and syntheses of drugs acting on cardiovascular system.
| 3,4,5,9 | 1,4,5,6, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Adrenergic drugs, adrenergic blocking drugs, cholinergic drugs, cholinergic blocking drugs, cardiac glycosides, antiarrhythmics, antianginal and vasodilator drugs, antihypertensives, antihyperlipidemics, coagulant and anticoagulant drugs, antianemic drugs, thrombolytics, antagonists and diuretics.
* Lab: Paper, thin layer, column and high pressure liquid chromatography techniques, and their applications in drug analysis. Separation of solid-solid and liquid-liquid mixtures. Determination of physical constants such as density, boiling and melting point, measurement of refraction index, determination of specific rotation. Determination of drug metabolites and pharmacopoeial analysis. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Adrenergic drugs, and adrenergic blocking drugs
*Lab.:What is chromatography? what are the principles?-demo | | | Week 2 | Adrenergic drugs, and adrenergic blocking drugs
*Lab.:types of chromatographic methods-demo | | | Week 3 | cholinergic agents, cholinergic blocking drugs
*Lab.: molecular weight determination, density determination, melting point determination, boiling point determination, refractometry, polarimetry-demo | | | Week 4 | cholinergic agents, cholinergic blocking drugs
*Lab.:Determination of liquid density * Separation test of liquid-liquid mixtures | | | Week 5 | cardiac glycosides, antiarrhythmics
*Lab.:Determination of solid density * Separation test of solid mixtures | | | Week 6 | cardiac glycosides, antiarrhythmics
*Lab.:polarimetry * determination of melting point | | | Week 7 | antianginal and vasodilator drugs
*Lab.:refractometry * determination of boiling point | | | Week 8 | Midterm exam | | | Week 9 | antianginal and vasodilator drugs
*Lab.:Pharmacopoeial analysis (distilled water + urea) test | | | Week 10 | antihypertensives, antihiperlipidemikler
*Lab.:chromatography (amino acid determination) *Pharmacopoeial analysis (NaCl) test | | | Week 11 | antihypertensives,
*Lab.: drug metabolism experiment | | | Week 12 | antihyperlipidemics
*Lab.: colon chromatography experiment | | | Week 13 | coagulant and anticoagulant drugs, antianemik drugs, thrombolytics
*Lab.:homework presentation (physicochemical properties, pharmacokinetic properties, receptor interactions, synthesis, structure activity relationships, pharmacological activities in drug molecules) | | | Week 14 | coagulant and anticoagulant drugs, antianemik drugs, thrombolytics
*Lab.:homework presentation (physicochemical properties, pharmacokinetic properties, receptor interactions, synthesis, structure activity relationships, pharmacological activities in drug molecules) | | | Week 15 | antiplatelet drugs and diuretics
*Lab.:compensation | | | Week 16 | Final exam | | | |
| 1 | Akgün, H., Balkan, A., Bilgin, A.A., Çalış, Ü., Dalkara, S., Erdoğan, H., Erol Demir, D., Ertan, M.,Gökhan, N., Özkanlı, F., Palaska, E., Saraç, S. ve Şafak, C., Tozkoparan.B.: Farmasötik Kimya, Ankara, 2004 | | | 2 | Delgado JN, Remers WA Wilson and Gisvolds Textbook of Organic Medicinal and Pharmaceutical Chemistry Philadelphia1991 Mutschler E, Derendorf H, Schafer-Korting M, Elrod K, Estes KS, Drug Actions, Stuttgart 1995 | | | 3 | Farmasötik Kimya Laboratuvar Çalışmaları II, H.Ü Eczacılık Fakültesi Farmasötik Kimya Anabilim Dalı Yayını, Ankara, 2004.Stahl, E.,Thin-layer Chromatography, 2nd edition, Springer-Verlag, New York, 1969. | | | 4 | Miller, J.A., Neuzil, E.F., Modern Experimental Organic Chemistry, D.C. Heath and Company, Lexington, Massachusetts, 1982.Ergenç, N., Gürsoy, A., Ateş, Ö.,İlaçların Tanınması ve Kantitatif Tayini, Matbaacılık, İstanbul, 1999. | | | 5 | Foye WO Principles of Medicinal Chemistry Philadelphia1989Korolkovas A Essentials of Medicinal Chemistry New York 1988 | | | 6 | Wolff ME Burgers Medicinal Chemistry and Drug Discovery New York 1997 | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 21.11.2021 | 2 | 30 | | Laboratory exam | 9 | 21.11.2021 | 2 | 20 | | Presentation | 14 | 10.12.2021 | 3 | 10 | | End-of-term exam | 16 | 11.01.2022 | 2 | 40 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 13 | 39 | | Laboratuar çalışması | 3 | 13 | 39 | | Arasınav | 2 | 1 | 2 | | Kısa sınav | 2 | 1 | 2 | | Dönem sonu sınavı | 2 | 1 | 2 | | Total work load | | | 84 |
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