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| ECZ3018 | Basic principals of drug development | 2+0+0 | ECTS:4 | | Year / Semester | Spring Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Dr. Öğr. Üyesi Elif Nur BARUT | | Co-Lecturer | | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | It is aimed to provide information about drug discovery, drug development stages and current developments in this field. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Students know the preclinical processes followed in drug development | 3,6,9 | 1, | | LO - 2 : | Students know the clinical processes followed in drug development | 3,6,9 | 1, | | LO - 3 : | Students know current technological developments used during drug discovery | 3,6,9 | 1, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| History of drug discovery, drug targets and drug development strategies suitable for these targets, repositioning approaches in drug discovery and the role of artificial intelligence in these processes, drug discovery processes in some special conditions (rare diseases, pandemics..), biotechnological drug concept, clinical drug research processes and legal regulations |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Historical process of drug discovery | | | Week 2 | Drug sources | | | Week 3 | drug targets | | | Week 4 | Stages of designing target molecules-1 | | | Week 5 | Stages of designing target molecules-2 | | | Week 6 | Drug repositioning | | | Week 7 | Prodrugs and development processes | | | Week 8 | Drug discovery in pandemics | | | Week 9 | Exam | | | Week 10 | Drug discovery in rare diseases | | | Week 11 | Biotechnological drugs and development processes | | | Week 12 | Personalized medicine development processes | | | Week 13 | Artificial intelligence in drug development | | | Week 14 | Clinical drug research and legal regulations-1 | | | Week 15 | Clinical drug research and legal regulations-2 | | | Week 16 | Exam | | | |
| 1 | Chorgrade M. Drug Discovery and Development, Wiley 2007. | | | |
| 1 | Kayaalp SO. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, 13. baskı, 2012. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | Nisan 2024 | 1 | 50 | | End-of-term exam | 16 | Haziran 2024 | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 14 | 28 | | Arasınav için hazırlık | 5 | 6 | 30 | | Arasınav | 1 | 1 | 1 | | Dönem sonu sınavı için hazırlık | 6 | 8 | 48 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 108 |
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