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| ECZ3002 | Free radicals and antioxidants | 2+0+0 | ECTS:4 | | Year / Semester | Spring Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Prof. Dr. Oktay YILDIZ | | Co-Lecturer | none | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | How radicals causing toxic effect form and the dismutation reactions occuring against this toxic effect will be enlightened by discussing permanent damages, degenerative diseases and ageing periods which occur in organism in the case of imbalance between radicals and defence system although there is an antioxidant defence system on the purpose of scavenging these free radicals forming in metabolism. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Have a full information about free radicals, | 4,8,10 | 1, | | LO - 2 : | Comprehend enzymatic and non-enzymatic antioxidant systems | 4,8,10 | 1, | | LO - 3 : | Understand scavenging mechanisms of free oxygen radicals by antioxidants | 4,8,10 | 1, | | LO - 4 : | Examine roles of antioxidants in ageing, nutrition, diseases and therapy. | 4,8,10 | 1, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Have a full information about free radicals, Comprehend enzymatic and non-enzymatic antioxidant systems, Understand scavenging mechanisms of free oxygen radicals by antioxidants, Correlate between oxidative stress and diseases, Examine roles of antioxidants in ageing, nutrition, diseases and therapy, innovative approaches. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introduction to Oxygen Toxicity ve Reactive Oxygen Species | | | Week 2 | Free Radical Species | | | Week 3 | Free Radical Sources in Aerobes | | | Week 4 | Antioxidant and Defence Enzymes: Superoxide Dismutases (SOD) | | | Week 5 | Antioxidant and Defence Enzymes: Catalases | | | Week 6 | Antioxidant and Defence Enzymes: Glutathione Peroxidase Family | | | Week 7 | Glutathione Metabolism: Glutathione Peroxidase, Glutathione S-Transferase, Glutathione Reductase | | | Week 8 | Other Antioxidant Enzymes: Cytochrome c Oxidase, NADPH Peroxidase/Oxidase | | | Week 9 | Midterm Exam | | | Week 10 | Non-Enzymatic Antioxidant System: Ascorbic Acid, Vitamine E, - Tocopherol | | | Week 11 | Antioxidant Defence with Low Molecular Weight Agents: Bilirubin, Melatonin, Coenzyme Q, Dipeptides Including Histidine | | | Week 12 | Roles of Metal Ions in Antioxidant Defence System | | | Week 13 | Oxidative Stress and Diseases; The Roles of Antioxidants in Ageing, Nutrition, Diseases and Therapy | | | Week 14 | Homework and Presentations | | | Week 15 | Homework and Presentations | | | Week 16 | Final exam | | | |
| 1 | Barry Halliwell and John M. C. Gutteridge, Free Radicals in Biology and Medicine, Oxford Science Publications, 2001. | | | |
| 1 | Ruma Banerjee, Donald Becker, Martin Dickman, Vadim Gladyshev, Stephen Ragsdale, Redox Biochemistry, Wiley, 2007. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 17/04/2024 | 1 | 50 | | End-of-term exam | 16 | 06/2024 | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 14 | 28 | | Arasınav için hazırlık | 1 | 7 | 7 | | Arasınav | 1 | 1 | 1 | | Ödev | 1 | 6 | 6 | | Kısa sınav | 1 | 1 | 1 | | Dönem sonu sınavı için hazırlık | 2 | 8 | 16 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 60 |
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