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| ECZ3047 | Clinical Chemisrty | 2+0+0 | ECTS:2 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Compulsory | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Dr. Öğr. Üyesi Merve BADEM | | Co-Lecturer | Res. Assist. PhD. Şeyda KANBOLAT | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | The course includes introducing diseases based on metabolic disorders of biomolecules in living systems; It is aimed to define the concepts of clinical biochemical analysis methods performed on biological materials for the diagnosis, treatment and treatment of these diseases. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Basic concepts of biological samples used in clinical biochemistry laboratories, collection and analysis of these samples are learned. | 1,2,6,7 | 1, | | LO - 2 : | The uses of enzymes in clinical diagnosis are learned. | 1,2,6,7 | 1, | | LO - 3 : | Biochemical parameters associated with hematological disorders can be evaluated. | 1,2,6,7 | 1, | | LO - 4 : | Clinical parameters associated with carbohydrate metabolism disorders can be evaluated.
| 1,2,6,7 | 1, | | LO - 5 : | Clinical parameters associated with lipid metabolism disorders can be evaluated. | 1,2,6,7 | 1, | | LO - 6 : | Clinical parameters associated with protein metabolism disorders can be evaluated. | 1,2,6,7 | 1, | | LO - 7 : | Parameters related to organ-specific pathological phenomena such as liver and kidney can be evaluated. | 1,2,6,7 | 1, | | LO - 8 : | The biochemical importance of tumor markers in the clinic is learned. | 1,2,6,7 | 1, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Definition of clinical biochemistry; identification, collection and storage of biological samples; factors affecting laboratory analysis; examination of enzymes that play a role in clinical diagnosis and their properties; blood lipids, the structure of plasma lipoproteins and lipid metabolism disorders; identification of plasma proteins (transferrin, ceruloplasmin, albumin, etc.) and their importance in clinical diagnosis, biochemical basis of kidney diseases and kidney function tests; biochemical structure of the liver and liver function tests; study of bile, gallstones and iron metabolism; identification of tumor markers |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introduction to Clinical Biochemistry
Definition of clinical biochemistry, organization of the clinical biochemistry laboratory, identification, collection and storage of biochemical samples used in analysis. | | | Week 2 | Factors Affecting Analysis Results
Identification of preanalytical, analytical and postanalytical factors affecting test results in laboratory analyses.
| | | Week 3 | Blood Analysis
Blood biochemistry, identification of parameters related to hematological disorders
| | | Week 4 | Blood Glucose
Carbohydrate metabolism disorders, diabetes and diabetes-related tests | | | Week 5 | Enzymes Used in Clinical Diagnosis
Definition of enzyme, properties of enzymes used in clinical diagnosis, specific-nonspecific enzymes associated with pathological conditions | | | Week 6 | Blood Lipids-1
Lipids, structure of lipoproteins, plasma lipids | | | Week 7 | Blood Lipids-2
Lipid metabolism disorders: dyslipidemias, sphingolipidoses, lipodystrophies, atherosclerosis | | | Week 8 | Case report | | | Week 9 | Midterm exam | | | Week 10 | Blood Proteins-1
Properties of plasma proteins and determination methods
| | | Week 11 | Blood Proteins-2
Clinical use of related parameters such as dysproteinemias, transferrin, albumin, CRP, ceruloplasmin, immunoglobulin, etc.
| | | Week 12 | Liver Function Tests
Analysis of parameters related to liver structure, function and liver disorders
| | | Week 13 | Kidney Function Tests
Analysis of kidney structure, function and parameters related to kidney functions | | | Week 14 | Urine Analysis, Electrolytes and Acid Base Balance
Urine biochemistry, collection of urine samples, physical properties and chemical composition of urine
| | | Week 15 | Tumor Markers
Clinical use of parameters related to Cancer, Malignancies
| | | Week 16 | Final Exam | | | |
| 1 | Klinik Biyokimya -Prensipler, Teknikler ve Korelasyonlar- (M. L. Bishop Lippincott Williams & Wilkins) | | | 2 | Ders notları | | | |
| 1 | Murray RK, Granner DK, Mayes PA and Rodwell WW. Harper?s Biochemistry, Stamford: Appleton. Lange, 1996. | | | 2 | Burtis CA, Ashwood ER: Tietz Textbook of Clinical Chemistry, USA: W.B. Saunders Company, 1994. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 29/11/2023 | 1 | 50 | | End-of-term exam | 16 | 10/01/2024 | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 14 | 28 | | Arasınav için hazırlık | 2 | 4 | 8 | | Arasınav | 1 | 1 | 1 | | Dönem sonu sınavı için hazırlık | 3 | 4 | 12 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 50 |
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