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| ECZ4045 | Pharmaceutical Toxicology - I | 2+0+0 | ECTS:3 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Compulsory | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Doç. Dr. Can Özgür YALÇIN | | Co-Lecturer | Assoc. Prof. Can Ozgur YALCIN, Ph.D. | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | The aim of the course; To give information about the general concept of toxicology, toxic dose and dose response relation, introduction routes of toxic substances, toxicokinetics and toxicodinamics of poisons, polymorphism, mutagenicity, teratogenicity carcinogenesis and drug-drug interactions, systemic toxicity and risk assessment. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | History and general concepts of toxicology, toxic substances absorption, distribution and excretion
| 1 | 1, | | LO - 2 : | Factors affecting toxicity, toxic effects, classification, mutagenicity and mutagenic agents, teratogenicity, and teratogenic agents and carcinogenicity and carcinogenic agents
| 1 | 1, | | LO - 3 : | Evaluation of drug drug interaction | 1 | 1, | | LO - 4 : | Systemic toxicity | 1 | 1, | | LO - 5 : | Toxicological Risk Assessment | 1 | 1, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| History of toxicology and general concepts; dose and dose response relationship; absorption, distribution and excretion of toxic substances; biotransformation of toxic substances; mechanisms of toxic effects; factors affecting toxicity; classification of toxic effects; genetic polymorphism; mutagenicity and mutagenic agents; teratogenicity and teratogenic agents; carcinogenicity and carcinogenic agents; toxicological assessment of drug-drug interactions, systemic toxiciy, and toxicological risk assessment. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | History and general concepts of toxicology | | | Week 2 | Toxicokinetic-Toxicodynamic-I | | | Week 3 | Toxicokinetic-Toxicodynamic-II | | | Week 4 | Factors Affecting Metabolism (Enzyme Inhibition, Enzyme Induction, and Genetic Polymorphisms) | | | Week 5 | Mutagenicity | | | Week 6 | Carcinogenicity | | | Week 7 | Teratogenicity
| | | Week 8 | General Principles of Poisonings & Antidotes | | | Week 9 | Midterm Exam | | | Week 10 | Toxicological Risk Assessment | | | Week 11 | Hepatotoxicity | | | Week 12 | Nephrotoxicity | | | Week 13 | Neurotoxicity | | | Week 14 | Cardiotoxicity, Pulmonary, Musculoskeletal & Endocrine System Toxicity | | | Week 15 | Hematotoxicity & Immunotoxicity | | | Week 16 | Final Exam | | | |
| 1 | Klaassen C.D., Watkins III J.B., Casarett and Doull's Essentials of Toxicology, The McGraw-Hill Companies, USA, 2019. | | | 2 | Erdem O., Bacanlı M., Temel Toksikoloji, Nobel Tıp Kitapevi, Ankara, 2021. | | | |
| 1 | Başaran N., Baydar T., Bucurgat-Ündeğer Ü. vd., Toksikoloji, Hacettepe Üniversitesi Yayınları, Ankara, 2020. | | | 2 | Vural N., Farmasötik Toksikoloji, Ankara Üniversitesi Yayınları, Ankara, 2017. | | | 3 | Mulder G.J., Dencker L., (Çeviri) Farmasötik Toksikoloji, Nobel Tıp Kitabevleri, Ankara, 2020. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 25/11/2023 | 1 | 50 | | End-of-term exam | 16 | 12/01/2024 | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 14 | 28 | | Sınıf dışı çalışma | 0 | 0 | 0 | | Laboratuar çalışması | 0 | 0 | 0 | | Arasınav için hazırlık | 2 | 9 | 18 | | Arasınav | 1 | 1 | 1 | | Uygulama | 0 | 0 | 0 | | Klinik Uygulama | 0 | 0 | 0 | | Ödev | 0 | 0 | 0 | | Proje | 0 | 0 | 0 | | Kısa sınav | 0 | 0 | 0 | | Dönem sonu sınavı için hazırlık | 2 | 14 | 28 | | Dönem sonu sınavı | 2 | 1 | 2 | | Diğer 1 | 0 | 0 | 0 | | Diğer 2 | 0 | 0 | 0 | | Total work load | | | 77 |
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