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| ECZ4033 | Pharmaceutical Chemistry - III | 2+0+0 | ECTS:3 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Compulsory | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Dr. Öğr. Üyesi Hasan Erdinç SELLİTEPE | | Co-Lecturer | Assist. Prof. Hasan Erdinç Sellitepe, Assist. Prof Sevda TÜRK, Res. Assist. Ahmet Buğra Aksel | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | nervous system physiological anatomical recall, drugs used in the nervous system synthesis, structure-activity metabolism reactions, classification.
This course is designed to provide the students with a general knowledge on central anesthesia, sedatives and hypnotics, tranquilizers, neuroleptics, anticonvulsant drugs, centrally acting muscle relaxant drugs and analgesic drugs and their classification, synthesis reactions, structure-activity relationships and metabolites.
* lab .: provides basic concepts on the different methods used in the quantitative analysis of drugs. It is also expected that learners will learn how to apply the quantitative method used in drug analysis. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | classification of drugs acting on autonomous nervous system. | 3,4,5,9 | 1,3,4, | | LO - 2 : | analyse the structure-activity relationships of drugs acting on central nervous system. | 3,4,5,9 | 1,4,5, | | LO - 3 : | analyse the synthesis of drugs acting on central nervous system. | 3,4,5,9 | 1,4,5, | | LO - 4 : | analyse the pharmacological activity of drugs acting on central nervous system. | 3,4,5,9 | 1,4,5, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| central nervous system drugs: general anesthetics, sedatives and hypnotics, tranquilizers, neuroleptics, anticonvulsant drugs, central acting muscle relaxants and analgesics.
* Lab.: Fundamentals of quantitative analysis; Titrimetry and neutralization, oximido-reduction, complexometry, nitrimometry and their applications in drug analysis. Light, spectrophotometric methods, derivative spectroscopy. Quantitative determination in pharmaceutical preparations. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | nervous system introduciton and terms
*lab.:quantitative analysis -demo | | | Week 2 | general anesthetic drugs
*lab.:polarimetry and colorimetry-demo | | | Week 3 | sedatives hypnotic drugs
*lab.:Alkalimetry | | | Week 4 | trankilisant drugs
*lab.:neutralization | | | Week 5 | noroleptic drugs
*lab.:Nitritometry | | | Week 6 | Centrally acting muscle relaxant drugs, anticonvulsant drugs
*lab.:Neutralization- (Determination of Lidocaine Hydrochloride Quantity) | | | Week 7 | anticonvulsant drugs
*lab.:ıodometry | | | Week 8 | midterm exam | | | Week 9 | narcotic anagesic drugs
*lab.:Permanganimetry | | | Week 10 | narcotic antagonist drugs
*lab.:Iodometry - (Isoniazid (INH) Quantification Assay) | | | Week 11 | local anesthetic drugs
*lab.:colorimetry | | | Week 12 | antidepresant drugs
*lab.:quantity determination with titration | | | Week 13 | anticancer drugs
*lab.:homework presentation (pharmacological, pharmacokinetic, physicochemical properties of drug molecules, synthesis and QSAR information) | | | Week 14 | antiviral drugs
*lab.:homework presentation (pharmacological, pharmacokinetic, physicochemical properties of drug molecules, synthesis and QSAR information) | | | Week 15 | nootrop drugs and analeptic drugs
*lab.:compensation | | | Week 16 | final examination | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 04/2019 | 2 | 30 | | Laboratory exam | 9 | 04/2019 | 2 | 15 | | Presentation | 14 | 05/2019 | 3 | 5 | | End-of-term exam | 16 | 05/2019 | 3 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 16 | 48 | | Laboratuar çalışması | 3 | 16 | 48 | | Arasınav için hazırlık | 1 | 1 | 1 | | Arasınav | 2 | 1 | 2 | | Ödev | 1 | 2 | 2 | | Dönem sonu sınavı için hazırlık | 2 | 1 | 2 | | Dönem sonu sınavı | 3 | 2 | 6 | | Total work load | | | 109 |
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