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| ECZ3027 | Pharmaceutical Chemistry - I | 2+0+0 | ECTS:4 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Compulsory | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Dr. Öğr. Üyesi Hasan Erdinç SELLİTEPE | | Co-Lecturer | Assoc. Prof. İnci Selin Doğan, Asst. Prof. Sevda Türk | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | The definition of pharmaceutical chemistry, history, effects of physicochemical and structural properties of drugs on activity, drug-receptor interactions, metabolism reactions of drugs and its importance in terms of drug development; general anesthetics, sedatives and hypnotics, tranquilizers, neuroleptics, centrally acting muscle relaxants and local anesthetics from central nervous system drugs and their classification, synthesis reactions, structure-activity relationships and metabolites. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Define general concepts of pharmaceutical chemistry. | 3,4,5,9 | 1, | | LO - 2 : | Classify central nervous system drugs and local anesthetics, discuss structure-activity relationships. | 3,4,5,9 | 1, | | LO - 3 : | Have knowledge about the synthesis of central nervous system drugs and local anesthetics. | 3,4,5,9 | 1, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Introduction to pharmaceutical chemistry and general concepts, biotransformation of drugs, structure-activity relationships, QSAR, receptor-drug interactions, drug organism and pharmacokinetic principles, drug design and new drug development. Central nervous system drugs: general anesthetics, sedatives and hypnotics, tranquilizers, neuroleptics, centrally acting muscle relaxants and local anesthetics. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introduction and general concepts of pharmaceutical chemistry
| | | Week 2 | Introduction and general concepts of pharmaceutical chemistry | | | Week 3 | Receptors, binding interactions and stereochemistry | | | Week 4 | Receptors, binding interactions and stereochemistry | | | Week 5 | SAR of drugs | | | Week 6 | Biotransformation of drugs
| | | Week 7 | Introduction and terms of the nervous system | | | Week 8 | General anesthetic drugs | | | Week 9 | Middle Exam | | | Week 10 | Sedative-hypnotic drugs | | | Week 11 | Sedative-hypnotic drugs | | | Week 12 | Tranquilizers | | | Week 13 | Neuroleptic drugs | | | Week 14 | Central Muscle Relaxants | | | Week 15 | Local anesthetic drugs | | | Week 16 | Final Exam | | | |
| 1 | Akgün, H., Balkan, A., Bilgin, A.A., Çalış, Ü., Dalkara, S., Erdoğan, H., Erol Demir, D., Ertan, M.,Gökhan, N., Özkanlı, F., Palaska, E., Saraç, S. ve Şafak, C., Tozkoparan.B.: Farmasötik Kimya, Ankara, 2016. | | | |
| 1 | Hart Craine Hart, Organik Kimya, (Çeviri ed. Tahsin Uyar, Palme Yayıncılık, 2005), Houghton Mifflin Company, 1995. | | | 2 | T. W. Graham Solomons, C. B. Fryhle, Organic Chemistry, 7th Ed., (Çeviri Editörleri: Gürol Okay, Yılmaz Yıldırır, Literatür Yayıncılık, 2002), John Wiley & Sons, Toronto, 2000. | | | 3 | Foye's Principles of Medicinal Chemistry 7th Edition by Ph.D. Lemke, Thomas L. (Editor), Ph.D. Williams, David A. (Editor), Ph.D. Roche, Victoria F. (Editor), Ph.D. Zito, S. William (Editor) | | | 4 | An Introduction to Medicinal Chemistry İngilizce Baskı Graham Patrick | | | 5 | Wilson and Gisvold?s Textbook of Organıc Medicinal and Pharmaceutical Chemistry. 12th Edition. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 26.11.2023 | 1 | 50 | | End-of-term exam | 16 | 23.01.2024 | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 14 | 28 | | Arasınav için hazırlık | 5 | 7 | 35 | | Arasınav | 1 | 1 | 1 | | Dönem sonu sınavı için hazırlık | 6 | 7 | 42 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 107 |
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