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| ECZ3029 | Pharmaceutical Chemistry-I Laboratory | 0+0+3 | ECTS:2 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Compulsory | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 3 hours of laboratory per week | | Lecturer | Dr. Öğr. Üyesi Hasan Erdinç SELLİTEPE | | Co-Lecturer | Assoc. Prof. İnci Selin Doğan, Asst. Prof. Sevda Türk | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | General synthesis methods and separation and purification methods are to be given to the students in practice. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Define the general concepts related to drug synthesis and purification in pharmaceutical chemistry. | 1,2,5 | 1,4, | | LO - 2 : | Gains knowledge and skills about the general methods used in synthesis. | 1,2,5 | 1,4, | | LO - 3 : | Gains the skills to present drug molecules. | 1,2,5 | 5, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Organic reactions, nomenclature, functional groups, separation and purification methods (extraction, crystallization, filtration), synthesis of various molecules in the laboratory (acetylation, oxidation, esterification, diazolation, etc.) |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Nomenclature, functional groups | | | Week 2 | Organic reactions | | | Week 3 | Separation and purification methods, general laboratory procedures (weighing, heating-cooling, drying) | | | Week 4 | Synthesis of paracetamol and dibenzalacetone | | | Week 5 | Synthesis of aspirin and benzil | | | Week 6 | Synthesis of aurin tricarboxylic acid and benzilic acid | | | Week 7 | Synthesis of phenytoin and iodoform | | | Week 8 | 4-Nitroacetanilide and benzoic acid-benzyl alcohol synthesis | | | Week 9 | Midterm exam | | | Week 10 | 4-Nitroaniline and benzocaine synthesis | | | Week 11 | Synthesis of 4-iodonitrobenzene and urotropin | | | Week 12 | Synthesis of isoamyl acetate and sulfasalazine | | | Week 13 | Student presentations (Drug molecule) | | | Week 14 | Student presentations (Drug molecule) | | | Week 15 | Student presentations (Drug molecule) | | | Week 16 | Final exam | | | |
| 1 | Hart Craine Hart, Organik Kimya, (Çeviri ed. Tahsin Uyar, Palme Yayıncılık, 2005), Houghton Mifflin Company, 1995. | | | 2 | T. W. Graham Solomons, C. B. Fryhle, Organic Chemistry, 7th Ed., (Çeviri Editörleri: Gürol Okay, Yılmaz Yıldırır, Literatür Yayıncılık, 2002), John Wiley & Sons, Toronto, 2000. | | | 3 | Vogel A. ?A Textbook of Practical Organic Chemistry? London, 1970 | | | 4 | An Introduction to Medicinal Chemistry İngilizce Baskı Graham Patrick | | | 5 | Wilson and Gisvold?s Textbook of Organıc Medicinal and Pharmaceutical Chemistry. 12th Edition. | | | 6 | Akgün, H., Balkan, A., Bilgin, A.A., Çalış, Ü., Dalkara, S., Erdoğan, H., Erol Demir, D., Ertan, M.,Gökhan, N., Özkanlı, F., Palaska, E., Saraç, S. ve Şafak, C., Tozkoparan.B.: Farmasötik Kimya, Ankara, 2016 | | | 7 | Büyük Ölçekli ve Küçük Ölçekli Organik Kimya Deneyleri. Kenneth L. Williamson, Robert D. Minard, Katherine M. Masters PALME YAYINCILIK | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 26.01.2023 | 1 | 50 | | Presentation | 13
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15 | Ocak | 0,25 | 5 | | End-of-term exam | 16 | 19.01.2024 | 1 | 45 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 6 | 12 | | Laboratuar çalışması | 3 | 8 | 24 | | Arasınav için hazırlık | 1 | 7 | 7 | | Arasınav | 1 | 1 | 1 | | Dönem sonu sınavı için hazırlık | 1 | 7 | 7 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 52 |
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