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| ECZ3017 | Natural Drug Discovery | 2+0+0 | ECTS:4 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Prof. Dr. Gülin RENDA | | Co-Lecturer | | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Methods of drug development from natural sources, drug design and new drug development steps, purification, phytochemistry, European Standards in terms of natural products, examined the situation of herbal medicines in Turkey and the world |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Use basic phytochemical techniques. | 1,9 | 1,5,6, | | LO - 2 : | Compare natural origin products on the market in terms of legislation, content and quality characteristics. | 1,9 | 1,5,6, | | LO - 3 : | Design product formulation using natural source pharmaceutical raw materials. | 1,9 | 1,5,6, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Methods of drug development from natural sources, drug design and new drug development steps, phytochemistry, European Standards in terms of natural products, Status of herbal medicines in Turkey and the world. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Drug design and new drug development steps, usage patterns of drugs, purification, phytochemistry | | | Week 2 | Herbal tea preparation, traditional treatment systems | | | Week 3 | Phytochemical studies in plants, plant material extraction, extraction methods, primer and secondary metabolism products in plants, bioactivity guided isolation | | | Week 4 | Phytochemical studies in plants, plant material extraction, extraction methods, primer and secondary metabolism products in plants, bioactivity guided isolation | | | Week 5 | Chromatographic methods used during the production of drugs from natural sources, extraction | | | Week 6 | Chromatographic methods used during the production of drugs from natural sources, extraction | | | Week 7 | Biotechnological applications in pharmacognosy, biotechnological drugs | | | Week 8 | Secondary metabolite production from microorganisms | | | Week 9 | Midterm exam | | | Week 10 | A study on monographs and pharmacopoeias for natural products | | | Week 11 | Bioavailability and phytoquivalence in herbal products | | | Week 12 | Production and aims of genetically modified plants, licensing of herbal medicines in Europe and in Turkey, European Standards in terms of natural products, herbal medicines in Turkey and in the world | | | Week 13 | Licensing of herbal medicinal products and regulations, GMP and GAP procedures of herbal products, new product development | | | Week 14 | Students' term paper presentations | | | Week 15 | Students' term paper presentations | | | Week 16 | Final exam | | | |
| 1 | Bruneton, J. 1999; Pharmacognosy, Phytochemistry, Medicinal Plants, Lavosier. | | | 2 | Kumar, S., Jayaveera, K.N., 2014; A Textbook of Pharmacognosy and Phytochemistry, S Chand. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Presentation | 14,15 | 29/12/2023
05/01/2024 | 2 | 25 | | Homework/Assignment/Term-paper | 14,15 | 29/12/2023
05/01/2024 | 2 | 25 | | End-of-term exam | 1 | 20/01/2024 | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 12 | 24 | | Ödev | 1 | 9 | 9 | | Dönem sonu sınavı için hazırlık | 5 | 12 | 60 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 94 |
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