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| TMIK614 | Antibiotics & Resistance Development | 1+2+0 | ECTS:7.5 | | Year / Semester | Fall Semester | | Level of Course | Third Cycle | | Status | Compulsory | | Department | DEPARTMENT of MEDICAL MICROBIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face, Lab work | | Contact Hours | 14 weeks - 1 hour of lectures and 2 hours of practicals per week | | Lecturer | Prof. Dr. Gülçin BAYRAMOĞLU | | Co-Lecturer | None | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Cover general classification and broad aspects of antibiotics and resistance mechanisms |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | describe the pharmacologic properties of antimicrobial drugs | 1 - 3 - 5 - 6 - 8 | 1,2,3,5 | | PO - 2 : | describe the spectrum of activity of antimicrobial drugs
| 1 - 3 - 5 - 6 - 8 | 1,2,3,5 | | PO - 3 : | explain the modes of action of antimicrobial drugs. | 1 - 3 - 5 - 6 - 8 | 1,2,3,5 | | PO - 4 : | describe the mechanisms of antimicrobial drug resistance. | 1 - 3 - 4 - 5 - 6 - 8 | 1,2,3,5 | | PO - 5 : | performing, and interpreting of antimicrobial susceptibility testing
| 1 - 3 - 4 - 5 - 6 - 8 | 1,2,3,4,5 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Spectrum of antibiotics; their pharmacokinetics and side effects; resistance to antibiotics, specific resistance and antibiotics susceptibility tests |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Terminology | | | Week 2 | Pharmacokinetics and pharmacodynamics of Antimicrobial agents | | | Week 3 | Classification of antibacterial agents | | | Week 4 | Inhibitors of cell wall synthesis | | | Week 5 | Inhibitors of protein synthesis | | | Week 6 | Inhibitors of nucleic acid synthesis | | | Week 7 | Other agents | | | Week 8 | Mid-term exam | | | Week 9 | Mechanisms of resistance to antibacterial agents II | | | Week 10 | Susceptibility test methods:Dilution methods | | | Week 11 | Susceptibility test methods:Disk diffusion methods | | | Week 12 | Susceptibility test methods:Automated systems | | | Week 13 | Detection of Extended-Spectrum Beta-Lactamase (ESBL) | | | Week 14 | Detection of Vancomycin resistant enterococcus (VRE) | | | Week 15 | Detection of Methicillin-resistant Staphylococcus aureus(MRSA) | | | Week 16 | End-of-term exam | | | |
| 1 | Murray P.R. ,Baron E.J. , Pfaller M.A. , Yolken R.H., 2003; Manual of Clinical Microbiology, 8th ed. ASM Press, Washington, D.C. | | | 2 | Murray P.R., Rosenthal K.S., Kobayashi G.S., Pfaller M.A., 2002; Medical microbiology, 4th Ed. Mosby, St. Louis. | | | |
| 1 | Mims C, Dockrell HM, Goering RV, Roitt I, Wakelin D, Zuckerman M., 2004; Medical Microbiology, 3rd Edition, Mosby Ltd., London. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | | 1 | 20 | | Laboratory exam | 8 | | 1 | 10 | | Presentation | 12 | | 1 | 10 | | Homework/Assignment/Term-paper | 12 | | 1 | 10 | | End-of-term exam | 17 | | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 1 | 16 | 16 | | Laboratuar çalışması | 2 | 16 | 32 | | Arasınav için hazırlık | 3 | 16 | 48 | | Arasınav | 2 | 2 | 4 | | Uygulama | 1 | 16 | 16 | | Ödev | 2 | 8 | 16 | | Dönem sonu sınavı için hazırlık | 3 | 16 | 48 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 181 |
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