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| MIK 613 | Virulence Mec.In M.Organisms | 2+0+0 | ECTS:7.5 | | Year / Semester | Fall Semester | | Level of Course | Third Cycle | | Status | Elective | | Department | DEPARTMENT of MEDICAL MICROBIOLOGY | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face, Group study, Lab work | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Dr. Öğr. Üyesi Metin SANCAKTAR | | Co-Lecturer | Asst. Prof. Dr. C. Kurtuluş BURUK, Assoc. Prof. Dr. İlknur TOSUN | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | ObjectivesCovers critical aspects of mechanisms by which microorganisms cause cellular destruction leading to inflammation process. |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | Student will be able to describe about of bacterial virulance. | 1 | 1,3 | | PO - 2 : | Student will be able to identify to virulance factors. | 1 | 1,3 | | PO - 3 : | Student will be able explain microorganisms relation of host cells. | 1 | 1,3 | | PO - 4 : | Student will summarize able to bacterial toxins. | 1 | 1,3 | | PO - 5 : | Student will be able to explain microorganisms relation of infectious diseases. | 1 | 1,3 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| ContentsAdherence, colonization, invasion; adaptation to live extracellular environment; development of resistance against cellular defense mechanisms; the nature of bacterial toxins; basic principles of virulence mechanisms. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Introduction to the Host-Parasite Interaction | | | Week 2 | Host Defenses Against Bacterial Pathogen | | | Week 3 | Clinical Importance of understanding Host defenses | | | Week 4 | Defenses of Body Surfaces | | | Week 5 | Host Defenses Against Bacterial Pathogen; Defenses of Tissue and Blood | | | Week 6 | Induced Defenses; Antibodies, Activated Macrophages, and Cytotoxic T Cells | | | Week 7 | Antibodies | | | Week 8 | Mid-term exam | | | Week 9 | Virulance factors that promote colonization | | | Week 10 | What is virulance? | | | Week 11 | Colonization and ınvasion of host surface | | | Week 12 | Evading Complement, Phagocytes, and the Antibody Response | | | Week 13 | Virulance factors that damage the host | | | Week 14 | Exotoxins, Hidrolytic enzimes | | | Week 15 | Bacterial products that provoke an autoimmune response | | | Week 16 | End-of-term exam | | | |
| 1 | Abiqail A.Salyers and Dixie D.Whitt; Bacterial Pathogenesis A Molecular Approach,2008 ;ASM Press, Washington, D.C. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | 07
11
2009 | 1 | 30 | | Homework/Assignment/Term-paper | 12 | 25
12
2009 | 1 | 20 | | End-of-term exam | 17 | 04
01
2010 | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 16 | 32 | | Sınıf dışı çalışma | 2 | 16 | 32 | | Laboratuar çalışması | 1 | 16 | 16 | | Arasınav için hazırlık | 2 | 8 | 16 | | Arasınav | 1 | 1 | 1 | | Ödev | 3 | 12 | 36 | | Dönem sonu sınavı için hazırlık | 6 | 4 | 24 | | Dönem sonu sınavı | 1 | 1 | 1 | | Total work load | | | 158 |
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