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| ECZ3047 | Clinical Chemisrty | 2+0+0 | ECTS:2 | | Year / Semester | Fall Semester | | Level of Course | Second Cycle | | Status | Compulsory | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Prof. Dr. Sermet YILDIRMIŞ | | Co-Lecturer | Assoc.Prof.Rezzan ALİYAZICIOĞLU, Assist.Prof.Sermet YILDIRMIŞ | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Provide general information on the principle of scientific and technological test about clinical biochemistry |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Explain what is the biochemical samples.
| 2 - 4 - 5 | 1, | | LO - 2 : | Sort importance of enzymes in the clinical diagnosis.
| 2 - 4 - 5 | 1, | | LO - 3 : | Sort importance of carbohydrate in the clinical diagnosis. | 2 - 4 - 5 | 1, | | LO - 4 : | Sort kidney function tests.
| 2 - 4 - 5 | 1, | | LO - 5 : | Define plasma lipids and atherosclerosis and sort their importance.
| 2 - 4 - 5 | 1, | | LO - 6 : | Know how to use plasma proteins in the clinic.
| 2 - 4 - 5 | 1, | | LO - 7 : | Give information about blood biochemistry. | 2 - 4 - 5 | | | LO - 8 : | Give information about urine tests. | 2 - 4 - 5 | 1, | | LO - 9 : | Sort the liver function tests.
| 2 - 4 - 5 | 1, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Biochemical Samples: Blood, Urine, Stool, Collecting of Cerebrospinal Fluid, Stabilization and Storage of Samples, Preanalytical Factors: Controlled and Uncontrolled Biological Factors, The Importance of Enzymes in Clinical Diagnosis: Description of the Enzyme, Targets of Enzyme Assay ,
The Importance of Plasma Proteins in Clinical Diagnosis: Hypoproteinemia, Serum Total Protein, Albumin, Ceruloplasmin, Transferrin, ?-1-acib Glycoprotein, Disorders of Carbohydrate Metabolism : Regulation of Blood Glucose Concentration, Plasma Lipids and Atherosclerosis: The General Structure and Function of Lipoproteins, Plasma Lipoprotein Disorders, Kidney Function Tests: Tubular Function, Water Reabsorption, The Biochemical Basis of Kidney Diseases, Liver Function Tests: Liver Function, Biochemical Tests, Bile, Gall Stones, Iron Metabolism and Anemia: Transferrin and Total Iron Binding Capacity, Plasma Ferritin Concentrations
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | The History of Clinical Biochemistry, Biochemical Samples: Blood, Urine, Collecting of Cerebrospinal Fluid, Stabilization and Storage of Samples | | | Week 2 | Preanalytical Factors: Controlled and Uncontrolled Biological Factors
| | | Week 3 | The Importance of Enzymes in Clinical Diagnosis: Description of the Enzyme, Targets of Enzyme Assay
| | | Week 4 | The Importance of Plasma Proteins in Clinical Diagnosis: Hypoproteinemia, Serum Total Protein, Albumin, Ceruloplasmin, Transferrin
| | | Week 5 | Disorders of Carbohydrate Metabolism : Regulation of Blood Glucose Concentration | | | Week 6 | Plasma Lipids and Atherosclerosis: The General Structure and Function of Lipoproteins, Plasma Lipoprotein Disorders
| | | Week 7 | Kidney Function Tests: Tubular Function, Water Reabsorption, The Biochemical basis of Kidney Diseases
| | | Week 8 | Blood Biochemistry | | | Week 9 | Midterm exam | | | Week 10 | Urine Biochemistry
| | | Week 11 | Liver Function Tests: Biochemical Tests, Bile, Gall Stones
| | | Week 12 | Iron Metabolism and Anemia: Transferrin and Total Iron Binding Capacity, Plasma Ferritin Concentrations
| | | Week 13 | Minerals and Bone Metabolism: Sodium, Potassium, Chloride, Calcium, Magnesium | | | Week 14 | Minerals and bone metabolism: Sodium, potassium, chloride, calcium, magnesium
| | | Week 15 | Endocrinology
| | | Week 16 | Final Exam | | | |
| 1 | Burtis CA, Ashwood ER: Tietz Textbook of Clinical Chemistry, USA: W.B. Saunders Company, 1994. | | | 2 | Stryer L. Biochemistry, ed 3. New York: WH Freeman, 1988. | | | 3 | Murray RK, Granner DK, Mayes PA and Rodwell WW. Harper?s Biochemistry, Stamford: Appleton. Lange, 1996. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 21/11/2021 | 1 | 50 | | End-of-term exam | 16 | 23/01/2022 | 1 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 14 | 28 | | Sınıf dışı çalışma | 3 | 10 | 30 | | Arasınav için hazırlık | 2 | 1 | 2 | | Arasınav | 3 | 5 | 15 | | Dönem sonu sınavı | 3 | 2 | 6 | | Total work load | | | 81 |
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