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| EBK5209 | Free Radicals and Antioxidant Systems | 3+0+0 | ECTS:7.5 | | Year / Semester | Spring Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of BIOCHEMISTRY (PHARMACY) | | Prerequisites and co-requisites | None | | Mode of Delivery | Face to face | | Contact Hours | 14 weeks - 3 hours of lectures per week | | Lecturer | Prof. Dr. Oktay YILDIZ | | Co-Lecturer | Assist. Prof. Dr. Sermet Yıldırmış | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Serbest radikalin tanımını, radikal reaksiyonların karakteristiklerini ve serbest radikal türlerini öğrenmek |
| Programme Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | PO - 1 : | the definition of oxidative stress | 4,8,11 | 1,3 | | PO - 2 : | The results of oxidative stress | 4,8,11 | 1,3 | | PO - 3 : | Oxidative stress biomarkers measured in various biological materials | 4,8,11 | 1,3 | | PO - 4 : | Diseases associated with free radicals | 5,8,11 | 1 | | PO - 5 : | Antioxidant system | 4,8,11 | 1,3 | | PO - 6 : | The role of antioxidants in treating the disease, clinical trials | 4,8,11 | 1,3 | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), PO : Learning Outcome | | |
| Serbest radikallerin endojen ve ekzojen kaynakları, Vücuttaki reaktif oksijen türlerinin hedefleri; proteinler, lipidler ve DNA?ya hasarları, Membran hasarı: lipid peroksidasyonu, mekanizmaları ve peroksit yıkılım ürünleri, Enzimatik antioksidanlar |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Definition of the free radical | | | Week 2 | Characteristics of radical reactions | | | Week 3 | Free radical species | | | Week 4 | Endogenous and exogenous sources of free radicals | | | Week 5 | Targets of reactive oxygen species in the body | | | Week 6 | Enzymatic antioxidants | | | Week 7 | The definition of oxidative stress, oxidative stress results | | | Week 8 | oxidative stress biomarkers measured in various biological materials | | | Week 9 | Mid-term exam | | | Week 10 | Introduction to diseases related to free radicals
| | | Week 11 | ischemia-reperfusion injury, cancer, aging
| | | Week 12 | eye diseases, inflammatory diseases, neurodegenerative diseases
| | | Week 13 | The role of antioxidants in treating the disease, clinical trials
| | | Week 14 | The use of compounds and antioxidant vitamins in the prevention of disease
| | | Week 15 | Clinical studies
| | | Week 16 | End-of-term exam | | | |
| 1 | Free Radicals, Oxidative Stress, and Antioxidants, Pathological and Physiological Significance, edited by Tomris Özben. | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 9 | 12.11.2021 | 1 saat | 50 | | End-of-term exam | 16 | 08.01.2021 | 1 saat | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 3 | 14 | 42 | | Sınıf dışı çalışma | 8 | 2 | 16 | | Arasınav için hazırlık | 8 | 2 | 16 | | Arasınav | 2 | 2 | 4 | | Ödev | 8 | 6 | 48 | | Kısa sınav | 2 | 2 | 4 | | Dönem sonu sınavı için hazırlık | 8 | 8 | 64 | | Dönem sonu sınavı | 2 | 1 | 2 | | Total work load | | | 196 |
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