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| ECZ3042 | Drug metabolism | 2+0+0 | ECTS:4 | | Year / Semester | Spring Semester | | Level of Course | Second Cycle | | Status | Elective | | Department | DEPARTMENT of PHARMACEUTICS | | Prerequisites and co-requisites | None | | Mode of Delivery | | | Contact Hours | 14 weeks - 2 hours of lectures per week | | Lecturer | Dr. Öğr. Üyesi Sevda TÜRK | | Co-Lecturer | | | Language of instruction | Turkish | | Professional practise ( internship ) | None | | | | The aim of the course: | | Giving general information on the basic concepts of drug metabolism, biotransformation reactions, functional groups in drug metabolism, enzymes involved in drug metabolism, enzyme inhibition and induction, reactive metabolites, factors affecting drug metabolism, stereochemistry of drug metabolism reactions, the concept of prodrug, the use of drug metabolism in the discovery of new drug active substances; to create awareness among students about this issue. |
| Learning Outcomes | CTPO | TOA | | Upon successful completion of the course, the students will be able to : | | | | LO - 1 : | Would be able to define general concepts related to drug metabolism. | 8,11,12 | 1, | | LO - 2 : | Would have an idea about enzymes involved in drug metabolism, enzyme inhibition and induction, reactive metabolites and factors affecting drug metabolism. | 2,8 | 1, | | LO - 3 : | Would be able to comprehend the importance of drug metabolism in biotransformation reactions and development of new drug candidates. | 1,4,7 | 1, | | CTPO : Contribution to programme outcomes, TOA :Type of assessment (1: written exam, 2: Oral exam, 3: Homework assignment, 4: Laboratory exercise/exam, 5: Seminar / presentation, 6: Term paper), LO : Learning Outcome | | |
| Basic concepts of drug metabolism, biotransformation reactions (Phase I, Phase II), functional groups in drug metabolism, enzymes in drug metabolism, enzyme inhibition and induction, reactive metabolites, factors affecting drug metabolism, stereochemistry of drug metabolism reactions, prodrug concept, use of drug metabolism in the discovery of new drug candidates. |
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| Course Syllabus | | Week | Subject | Related Notes / Files | | Week 1 | Basic information necessary to understand the biotransformation of drugs | | | Week 2 | Basic concepts in drug metabolism | | | Week 3 | Functional groups in drug metabolism | | | Week 4 | Phase I reactions; oxidation | | | Week 5 | Phase I reactions; reduction, hydrolysis | | | Week 6 | Enzymes involved in drug metabolism, enzyme inhibition and induction | | | Week 7 | Phase II reactions | | | Week 8 | Reactive metabolites | | | Week 9 | Midterm | | | Week 10 | Phase III reactions, biotransformation pathways of some drugs | | | Week 11 | Factors affecting drug metabolism | | | Week 12 | Stereochemistry of drug metabolism reactions | | | Week 13 | Prodrug concept | | | Week 14 | The use of drug metabolism in the discovery of new drug candidates | | | Week 15 | Prodrug approach in anticancer therapy | | | Week 16 | Final exam | | | |
| 1 | Akgün, H., Balkan, A., Bilgin, A.A., Çalış, Ü., Dalkara, S., Erdoğan, H., Erol Demir, D., Ertan, M.,Gökhan, N., Özkanlı, F., Palaska, E., Saraç, S. ve Şafak, C., Tozkoparan.B.: Farmasötik Kimya, Ankara, 2016. | | | |
| 1 | Foye's Principles of Medicinal Chemistry 7th Edition by Ph.D. Lemke, Thomas L. (Editor), Ph.D. Williams, David A. (Editor), Ph.D. Roche, Victoria F. (Editor), Ph.D. Zito, S. William (Editor) | | | |
| Method of Assessment | | Type of assessment | Week No | Date | Duration (hours) | Weight (%) | | Mid-term exam | 8 | | 2 | 50 | | End-of-term exam | 16 | | 2 | 50 | | |
| Student Work Load and its Distribution | | Type of work | Duration (hours pw) | No of weeks / Number of activity | Hours in total per term | | Yüz yüze eğitim | 2 | 14 | 28 | | Total work load | | | 28 |
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